Mitochondria are key organelles for cellular homeostasis. They generate the most part of
ATP that is used by cells through oxidative phosphorylation. They also produce reactive …

Mitochondria play a pivotal role in cellular energy-generating processes and are considered
master regulators of cell life and death fate. Mitochondrial function integrates signalling …

A critical role for mitochondrial dysfunction has been proposed in the pathogenesis of
Down's syndrome (DS), a human multifactorial disorder caused by trisomy of chromosome …

Ovarian cancer (OC) represents the main cause of death from gynecological malignancies
in western countries. Altered cellular and mitochondrial metabolism are considered …

Multiple sclerosis (MS) is a complex inflammatory and neurodegenerative chronic disease
that involves the immune and central nervous systems (CNS). The pathogenesis involves …

Ovarian cancer (OC) is the most lethal gynecologic cancer characterized by an elevated
apoptosis resistance that, potentially, leads to chemo-resistance in the recurrent disease …

Mitochondria, responding to a wide variety of signals, including oxidative stress, are critical
in regulating apoptosis that plays a key role in the pathogenesis of a variety of …

In mammals during aging, reactive oxygen species (ROS), produced by the mitochondrial
respiratory chain, cause oxidative damage of macromolecules leading to respiratory chain …

Complex I is the point of entry in the mitochondrial electron transport chain for NADH
reducing equivalents, and it behaves as a regulatable pacemaker of respiratory ATP …

Background Defective mitochondria and aberrant brain mitochondrial bioenergetics are
consistent features in syndromic intellectual disability disorders, such as Rett syndrome …