Type 2 diabetes (T2D) is a metabolic disorder characterized by hyperglycemia and insulin
resistance in which oxidative stress is thought to be a primary cause. Considering that …

The worldwide prevalence of non-alcoholic fatty liver disease (NAFLD) is estimated to have
reached 25% or more in adults. NAFLD is prevalent in obese individuals, but may also affect …

Metabolic flexibility is the ability to respond or adapt to conditional changes in metabolic
demand. This broad concept has been propagated to explain insulin resistance and …

There is significant evidence that, in living systems, free radicals and other reactive oxygen
and nitrogen species play a double role, because they can cause oxidative damage and …

Excessive accumulation of lipids can lead to lipotoxicity, cell dysfunction and alteration in
metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas …

In the transition from normal glucose tolerance (NGT) to type 2 diabetes mellitus (T2DM), the
role of β-cell dysfunction and peripheral insulin resistance (IR) is well established. However …

The gut microbiota has been implicated in obesity and cardiometabolic diseases, although
evidence in humans is scarce. We investigated how gut microbiota manipulation by …

metabolic control by either bariatric surgery or hypocaloric diet allows for the time sequence
of underlying pathophysiologic mechanisms to be observed. In reverse order, the same …

Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in
insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of …

Muscle insulin resistance is a key feature of obesity and type 2 diabetes and is strongly
associated with increased intramyocellular lipid content and inflammation. However, the …