[HTML][HTML] Relationship between oxidative stress, ER stress, and inflammation in type 2 diabetes: the battle continues
E Burgos-Morón, Z Abad-Jiménez… - Journal of clinical …, 2019 - mdpi.com
Type 2 diabetes (T2D) is a metabolic disorder characterized by hyperglycemia and insulin
resistance in which oxidative stress is thought to be a primary cause. Considering that …
resistance in which oxidative stress is thought to be a primary cause. Considering that …
[HTML][HTML] From NASH to diabetes and from diabetes to NASH: mechanisms and treatment options
A Gastaldelli, K Cusi - JHEP reports, 2019 - Elsevier
The worldwide prevalence of non-alcoholic fatty liver disease (NAFLD) is estimated to have
reached 25% or more in adults. NAFLD is prevalent in obese individuals, but may also affect …
reached 25% or more in adults. NAFLD is prevalent in obese individuals, but may also affect …
[HTML][HTML] Metabolic flexibility in health and disease
BH Goodpaster, LM Sparks - Cell metabolism, 2017 - cell.com
Metabolic flexibility is the ability to respond or adapt to conditional changes in metabolic
demand. This broad concept has been propagated to explain insulin resistance and …
demand. This broad concept has been propagated to explain insulin resistance and …
Role of ROS and RNS sources in physiological and pathological conditions
S Di Meo, TT Reed, P Venditti… - Oxidative medicine and …, 2016 - Wiley Online Library
There is significant evidence that, in living systems, free radicals and other reactive oxygen
and nitrogen species play a double role, because they can cause oxidative damage and …
and nitrogen species play a double role, because they can cause oxidative damage and …
[HTML][HTML] The subtle balance between lipolysis and lipogenesis: a critical point in metabolic homeostasis
Excessive accumulation of lipids can lead to lipotoxicity, cell dysfunction and alteration in
metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas …
metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas …
Role of adipose tissue insulin resistance in the natural history of type 2 diabetes: results from the San Antonio Metabolism Study
A Gastaldelli, M Gaggini, RA DeFronzo - Diabetes, 2017 - Am Diabetes Assoc
In the transition from normal glucose tolerance (NGT) to type 2 diabetes mellitus (T2DM), the
role of β-cell dysfunction and peripheral insulin resistance (IR) is well established. However …
role of β-cell dysfunction and peripheral insulin resistance (IR) is well established. However …
[HTML][HTML] Effects of gut microbiota manipulation by antibiotics on host metabolism in obese humans: a randomized double-blind placebo-controlled trial
D Reijnders, GH Goossens, GDA Hermes, EPJG Neis… - Cell metabolism, 2016 - cell.com
The gut microbiota has been implicated in obesity and cardiometabolic diseases, although
evidence in humans is scarce. We investigated how gut microbiota manipulation by …
evidence in humans is scarce. We investigated how gut microbiota manipulation by …
Type 2 diabetes: etiology and reversibility
R Taylor - Diabetes care, 2013 - Am Diabetes Assoc
metabolic control by either bariatric surgery or hypocaloric diet allows for the time sequence
of underlying pathophysiologic mechanisms to be observed. In reverse order, the same …
of underlying pathophysiologic mechanisms to be observed. In reverse order, the same …
The role of mitochondria in insulin resistance and type 2 diabetes mellitus
J Szendroedi, E Phielix, M Roden - Nature Reviews Endocrinology, 2012 - nature.com
Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in
insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of …
insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of …
Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans
J Szendroedi, T Yoshimura, E Phielix… - Proceedings of the …, 2014 - National Acad Sciences
Muscle insulin resistance is a key feature of obesity and type 2 diabetes and is strongly
associated with increased intramyocellular lipid content and inflammation. However, the …
associated with increased intramyocellular lipid content and inflammation. However, the …