One in 10 persons in the world aged 40 years and older will develop the syndrome of
HFpEF (heart failure with preserved ejection fraction), the most common form of chronic …

A hallmark of cardiac metabolism before birth is the predominance of carbohydrate use for
energy provision. After birth, energy substrate metabolism rapidly switches to the oxidation …

Background During the development of heart failure (HF), the chief myocardial energy
substrate switches from fatty acids to glucose. This metabolic switch, which recapitulates …

Ischemic heart disease remains one of the most prominent causes of mortalities worldwide
with heart transplantation being the gold-standard treatment option. However, due to the …

Engineering functional human cardiac tissue that mimics the native adult morphological and
functional phenotype has been a long held objective. In the last 5 years, the field of cardiac …

Using quantitative RT-PCR in RNA from right ventricular (RV) endomyocardial biopsies from
intact nonfailing hearts, and subjects with moderate RV failure from primary pulmonary …

Myocardial failure has been considered to be an irreversible and progressive process
characterized by ventricular enlargement, chamber geometric alterations, and diminished …

The cardiac response to increased work includes a reactivation of fetal genes. The response
to a decrease in cardiac work is not known. Such information is of clinical interest, because …

Abstract Methylation at 5-cytosine (5-mC) is a fundamental epigenetic DNA modification
associated recently with cardiac disease. In contrast, the role of 5-hydroxymethylcytosine (5 …

Mutations in LMNA, which encodes nuclear Lamins A and C cause diseases affecting
various organs, including the heart. We have determined the effects of an Lmna H222P …