Eukaryotic stress granules: the ins and outs of translation
The stress response in eukaryotic cells often inhibits translation initiation and leads to the
formation of cytoplasmic RNA-protein complexes referred to as stress granules. Stress …
formation of cytoplasmic RNA-protein complexes referred to as stress granules. Stress …
The multiple functions of RNA helicases as drivers and regulators of gene expression
CF Bourgeois, F Mortreux, D Auboeuf - Nature reviews Molecular cell …, 2016 - nature.com
RNA helicases comprise the largest family of enzymes involved in the metabolism of
mRNAs, the processing and fate of which rely on their packaging into messenger …
mRNAs, the processing and fate of which rely on their packaging into messenger …
[HTML][HTML] Pervasive downstream RNA hairpins dynamically dictate start-codon selection
Translational reprogramming allows organisms to adapt to changing conditions. Upstream
start codons (uAUGs), which are prevalently present in mRNAs, have crucial roles in …
start codons (uAUGs), which are prevalently present in mRNAs, have crucial roles in …
The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics
S Elbaum-Garfinkle, Y Kim… - Proceedings of the …, 2015 - National Acad Sciences
P granules and other RNA/protein bodies are membrane-less organelles that may assemble
by intracellular phase separation, similar to the condensation of water vapor into droplets …
by intracellular phase separation, similar to the condensation of water vapor into droplets …
An m6A-YTH Module Controls Developmental Timing and Morphogenesis in Arabidopsis
L Arribas-Hernández, S Bressendorff… - The Plant …, 2018 - academic.oup.com
Methylation of N6-adenosine (m6A) in mRNA is an important posttranscriptional gene
regulatory mechanism in eukaryotes. m6A provides a binding site for effector proteins …
regulatory mechanism in eukaryotes. m6A provides a binding site for effector proteins …
[HTML][HTML] Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation
Sex differences are pervasive in human health and disease. One major key to sex-biased
differences lies in the sex chromosomes. Although the functions of the X chromosome …
differences lies in the sex chromosomes. Although the functions of the X chromosome …
[HTML][HTML] The control of mRNA decapping and P-body formation
TM Franks, J Lykke-Andersen - Molecular cell, 2008 - cell.com
mRNA decapping is a critical step in eukaryotic cytoplasmic mRNA turnover. Cytoplasmic
mRNA decapping is catalyzed by Dcp2 in conjunction with its coactivator Dcp1 and is …
mRNA decapping is catalyzed by Dcp2 in conjunction with its coactivator Dcp1 and is …
Genome-wide analysis of translational efficiency reveals distinct but overlapping functions of yeast DEAD-box RNA helicases Ded1 and eIF4A
ND Sen, F Zhou, NT Ingolia, AG Hinnebusch - Genome research, 2015 - genome.cshlp.org
DEAD-box RNA helicases eIF4A and Ded1 are believed to promote translation initiation by
resolving mRNA secondary structures that impede ribosome attachment at the mRNA 5 …
resolving mRNA secondary structures that impede ribosome attachment at the mRNA 5 …
DEAD box RNA helicase functions in cancer
FV Fuller-Pace - RNA biology, 2013 - Taylor & Francis
Members of the DEAD box family of RNA helicases are known to be involved in most cellular
processes that require manipulation of RNA structure and, in many cases, exhibit other …
processes that require manipulation of RNA structure and, in many cases, exhibit other …
[HTML][HTML] The DEAD-box protein Ded1 modulates translation by the formation and resolution of an eIF4F-mRNA complex
The translation, localization, and degradation of cytoplasmic mRNAs are controlled by the
formation and rearrangement of their mRNPs. The conserved Ded1/DDX3 DEAD-box …
formation and rearrangement of their mRNPs. The conserved Ded1/DDX3 DEAD-box …