Our current knowledge of human memory CD8+ T cells is derived largely from studies of the
intravascular space. However, emerging data are starting to challenge some of the dogmas …

Epstein-Barr virus (EBV) provides a useful model to study cellular immunity to a genetically
stable, persistent human virus. Different sets of proteins expressed during EBV's lytic and …

CD8+ T lymphocytes play an important role in the control of intracellular pathogens during
both acute and persistent infections. This is particularly true in the case of persistent …

Vaccinia virus immunization provides lifelong protection against smallpox, but the
mechanisms of this exquisite protection are unknown. We used polychromatic flow cytometry …

The correlates of protective immunity to disease-inducing viruses in humans remain to be
elucidated. We determined the kinetics and characteristics of cytomegalovirus (CMV) …

The forces that govern clonal selection during the genesis and maintenance of specific T cell
responses are complex, but amenable to decryption by interrogation of constituent …

Epstein-Barr virus (EBV) infects most people and establishes life-long infection controlled by
the host's immune system. The genetic stability of the virus, deep understanding of the viral …

CD8+ T cells are essential in the defence against viruses. Recently, peptide–HLA class I
tetramers have been used to study immune responses to viruses in humans. This approach …

We have proposed that EBV uses mature B cell biology to access memory B cells as a site of
persistent infection. A central feature of this model is that EBV adapts its gene expression …

In response to infection or effective vaccination, naive antigen‐specific CD8+ T cells
undergo a dramatic highly orchestrated activation process. Initial encounter with an …