Structure, regulation and related diseases of the actin-binding protein gelsolin

J Feldt, M Schicht, F Garreis, J Welss… - Expert reviews in …, 2018 - cambridge.org
Gelsolin (GSN), one of the most abundant actin-binding proteins, is involved in cell motility,
shape and metabolism. As a member of the GSN superfamily, GSN is a highly structured …

Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention

JP Solomon, LJ Page, WE Balch… - Critical reviews in …, 2012 - Taylor & Francis
Protein misassembly into aggregate structures, including cross-β-sheet amyloid fibrils, is
linked to diseases characterized by the degeneration of post-mitotic tissue. While amyloid …

Exclusion of a Proton ATPase from the Apical Membrane Is Associated with Cell Polarity and Tip Growth in Nicotiana tabacum Pollen Tubes

AC Certal, RB Almeida, LM Carvalho, E Wong… - The Plant …, 2008 - academic.oup.com
Polarized growth in pollen tubes results from exocytosis at the tip and is associated with
conspicuous polarization of Ca2+, H+, K+, and Cl−-fluxes. Here, we show that cell polarity in …

[HTML][HTML] Disarrangement of actin filaments and Ca2+ gradient by CdCl2 alters cell wall construction in Arabidopsis thaliana root hairs by inhibiting vesicular trafficking

JL Fan, XZ Wei, LC Wan, LY Zhang, XQ Zhao… - Journal of plant …, 2011 - Elsevier
Cadmium (Cd), one of the most toxic heavy metals, inhibits many cellular and physiological
processes in plants. Here, the involvement of cytoplasmic Ca 2+ gradient and actin filaments …

Refrigerated storage of platelets initiates changes in platelet surface marker expression and localization of intracellular proteins

B Wood, MP Padula, DC Marks, L Johnson - Transfusion, 2016 - Wiley Online Library
BACKGROUND Platelets (PLTs) are currently stored at room temperature (22° C), which
limits their shelf life, primarily due to the risk of bacterial growth. Alternatives to room …

Neuronal cytoskeleton in intellectual disability: from systems biology and modeling to therapeutic opportunities

C Liaci, M Camera, G Caslini, S Rando… - International Journal of …, 2021 - mdpi.com
Intellectual disability (ID) is a pathological condition characterized by limited intellectual
functioning and adaptive behaviors. It affects 1–3% of the worldwide population, and no …

Myosin and gelsolin cooperate in actin filament severing and actomyosin motor activity

V Vemula, T Huber, M Ušaj, B Bugyi… - Journal of Biological …, 2021 - ASBMB
Actin is a major intracellular protein with key functions in cellular motility, signaling, and
structural rearrangements. Its dynamic behavior, such as polymerization and …

Gelsolin secretion in interleukin-4–treated bronchial epithelia and in asthmatic airways

G Candiano, M Bruschi, N Pedemonte… - American journal of …, 2005 - atsjournals.org
Rationale: The airway surface liquid, the thin layer of liquid covering the airways, is essential
for mucociliary clearance and as a barrier against microbial and other noxious agents …

On the mechanical stabilization of filopodia

A Zidovska, E Sackmann - Biophysical journal, 2011 - cell.com
We studied force-induced elongation of filopodia by coupling magnetic tweezers to the tip
through the bacterial coat protein invasin, which couples the force generator to the actin …

The interaction of gelsolin with tropomyosin modulates actin dynamics

S Khaitlina, H Fitz, H Hinssen - The FEBS journal, 2013 - Wiley Online Library
We have investigated the interactions between the actin‐binding proteins gelsolin and
tropomyosin, with special respect to any effects on the functional properties of gelsolin …