Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein
synthesis, folding, conformational maintenance, and degradation. A complex and adaptive …

The aggregation of specific proteins is hypothesized to underlie several degenerative
diseases, which are collectively known as amyloid disorders. However, the mechanistic …

Intensive scientific research devoted in the recent years to understand the molecular
mechanisms or neurodegeneration in spinocerebellar ataxias (SCAs) are identifying new …

Conspectus Molecular chaperones play a central role in protein homeostasis (aka
proteostasis) by balancing protein folding, quality control, and turnover. To perform these …

The molecular chaperones are central mediators of protein homeostasis. In that role, they
engage in widespread protein–protein interactions (PPIs) with each other and with their" …

The molecular chaperone, heat shock protein 70 (Hsp70), is an emerging drug target for
treating neurodegenerative tauopathies. We recently found that one promising Hsp70 …

Protein homeostasis, or proteostasis, refers to a proper balance between synthesis,
maturation, and degradation of cellular proteins. A growing body of evidence suggests that …

Heat shock protein 70 (Hsp70) is a molecular chaperone that plays critical roles in protein
homeostasis. Hsp70's chaperone activity is coordinated by intra-molecular interactions …

Protein homeostasis (proteostasis) refers to the ability of cells to preserve the correct
balance between protein synthesis, folding and degradation. Proteostasis is essential for …

Mutant protein aggregation is a hallmark of many neuro-degenerative diseases, including
the polyglutamine disorders. Although the correlation between aggregation formation and …