Selenium biofortification in the 21st century: status and challenges for healthy human nutrition

M Schiavon, S Nardi, F Dalla Vecchia, A Ertani - Plant and soil, 2020 - Springer
Abstract Background Selenium (Se) is an essential element for mammals and its deficiency
in the diet is a global problem. Plants accumulate Se and thus represent a major source of …

Food sources of selenium and its relationship with chronic diseases

W Hu, C Zhao, H Hu, S Yin - Nutrients, 2021 - mdpi.com
Selenium (Se) is an essential micronutrient for mammals, and its deficiency seriously
threatens human health. A series of biofortification strategies have been developed to …

Selenium-enriched plant foods: Selenium accumulation, speciation, and health functionality

P Tangjaidee, P Swedlund, J Xiang, H Yin… - Frontiers in …, 2023 - frontiersin.org
Selenium (Se) is an essential element for maintaining human health. The biological effects
and toxicity of Se compounds in humans are related to their chemical forms and …

Metabolism of selenium, selenocysteine, and selenoproteins in ferroptosis in solid tumor cancers

BK Shimada, S Swanson, P Toh, LA Seale - Biomolecules, 2022 - mdpi.com
A potential target of precision nutrition in cancer therapeutics is the micronutrient selenium
(Se). Se is metabolized and incorporated as the amino acid selenocysteine (Sec) into 25 …

Selenocompounds in cancer therapy: an overview

D Bartolini, L Sancineto, AF de Bem, KD Tew… - Advances in Cancer …, 2017 - Elsevier
In vitro and in vivo experimental models clearly demonstrate the efficacy of Se compounds
as anticancer agents, contingent upon chemical structures and concentrations of test …

FOXO transcription factors at the interface of metabolism and cancer

W Link, PJ Fernandez‐Marcos - International journal of cancer, 2017 - Wiley Online Library
Diabetes refers to a group of metabolic diseases characterized by impaired insulin
signalling and high blood glucose. A growing body of epidemiological evidence links …

The main cytotoxic effects of methylseleninic acid on various cancer cells

EG Varlamova, EA Turovsky - International Journal of Molecular Sciences, 2021 - mdpi.com
Studies of recent decades have repeatedly demonstrated the cytotoxic effect of selenium-
containing compounds on cancer cells of various origins. Particular attention in these …

Selenium effects on oxidative stress-induced calcium signaling pathways in Parkinson's disease

S Salaramoli, H Joshaghani, SI Hashemy - Indian Journal of Clinical …, 2022 - Springer
Parkinson's disease (PD) is a neurological disorder in which oxidative stress and reactive
oxygen species productions are proposed to be involved in its pathogenesis. Despite …

Emerging anticancer potentials of selenium on osteosarcoma

KL Pang, KY Chin - International journal of molecular sciences, 2019 - mdpi.com
Selenium is a trace element essential to humans and forms complexes with proteins, which
exert physiological functions in the body. In vitro studies suggested that selenium possesses …

Cytosolic and mitochondrial ROS production resulted in apoptosis induction in breast cancer cells treated with Crocin: The role of FOXO3a, PTEN and AKT signaling

A Nasimian, P Farzaneh, F Tamanoi… - Biochemical …, 2020 - Elsevier
Different groups have reported the Crocin anticancer activity. We previously showed Crocin-
induced apoptosis in rat model of breast and gastric cancers, through the increased Bax/Bcl …