Structures and general transport mechanisms by the major facilitator superfamily (MFS)
The major facilitator superfamily (MFS) is the largest known superfamily of secondary active
transporters. MFS transporters are responsible for transporting a broad spectrum of …
transporters. MFS transporters are responsible for transporting a broad spectrum of …
Theory and applications of differential scanning fluorimetry in early-stage drug discovery
K Gao, R Oerlemans, MR Groves - Biophysical reviews, 2020 - Springer
Differential scanning fluorimetry (DSF) is an accessible, rapid, and economical biophysical
technique that has seen many applications over the years, ranging from protein folding state …
technique that has seen many applications over the years, ranging from protein folding state …
[HTML][HTML] Crystal structure of the human cannabinoid receptor CB2
X Li, T Hua, K Vemuri, JH Ho, Y Wu, L Wu, P Popov… - Cell, 2019 - cell.com
The cannabinoid receptor CB2 is predominately expressed in the immune system, and
selective modulation of CB2 without the psychoactivity of CB1 has therapeutic potential in …
selective modulation of CB2 without the psychoactivity of CB1 has therapeutic potential in …
Crystal structure of the human cannabinoid receptor CB1
Summary Cannabinoid receptor 1 (CB 1) is the principal target of Δ 9-tetrahydrocannabinol
(THC), a psychoactive chemical from Cannabis sativa with a wide range of therapeutic …
(THC), a psychoactive chemical from Cannabis sativa with a wide range of therapeutic …
Structural basis of GABA reuptake inhibition
Abstract γ-Aminobutyric acid (GABA) transporter 1 (GAT1) regulates neuronal excitation of
the central nervous system by clearing the synaptic cleft of the inhibitory neurotransmitter …
the central nervous system by clearing the synaptic cleft of the inhibitory neurotransmitter …
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
G-protein-coupled receptors (GPCRs) signal primarily through G proteins or arrestins.
Arrestin binding to GPCRs blocks G protein interaction and redirects signalling to numerous …
Arrestin binding to GPCRs blocks G protein interaction and redirects signalling to numerous …
Cryo-EM structures of the TMEM16A calcium-activated chloride channel
Calcium-activated chloride channels (CaCCs) encoded by TMEM16A,, control neuronal
signalling, smooth muscle contraction, airway and exocrine gland secretion, and rhythmic …
signalling, smooth muscle contraction, airway and exocrine gland secretion, and rhythmic …
A complex structure of arrestin-2 bound to a G protein-coupled receptor
Arrestins comprise a family of signal regulators of G-protein-coupled receptors (GPCRs),
which include arrestins 1 to 4. While arrestins 1 and 4 are visual arrestins dedicated to …
which include arrestins 1 to 4. While arrestins 1 and 4 are visual arrestins dedicated to …
The molecular mechanism of transport by the mitochondrial ADP/ATP carrier
JJ Ruprecht, MS King, T Zögg, AA Aleksandrova… - Cell, 2019 - cell.com
Mitochondrial ADP/ATP carriers transport ADP into the mitochondrial matrix for ATP
synthesis, and ATP out to fuel the cell, by cycling between cytoplasmic-open and matrix …
synthesis, and ATP out to fuel the cell, by cycling between cytoplasmic-open and matrix …
Anionic phospholipids control mechanisms of GPCR-G protein recognition
G protein-coupled receptors (GPCRs) are embedded in phospholipids that strongly
influence drug-stimulated signaling. Anionic lipids are particularly important for GPCR …
influence drug-stimulated signaling. Anionic lipids are particularly important for GPCR …