Structures and general transport mechanisms by the major facilitator superfamily (MFS)

D Drew, RA North, K Nagarathinam… - Chemical reviews, 2021 - ACS Publications
The major facilitator superfamily (MFS) is the largest known superfamily of secondary active
transporters. MFS transporters are responsible for transporting a broad spectrum of …

Theory and applications of differential scanning fluorimetry in early-stage drug discovery

K Gao, R Oerlemans, MR Groves - Biophysical reviews, 2020 - Springer
Differential scanning fluorimetry (DSF) is an accessible, rapid, and economical biophysical
technique that has seen many applications over the years, ranging from protein folding state …

[HTML][HTML] Crystal structure of the human cannabinoid receptor CB2

X Li, T Hua, K Vemuri, JH Ho, Y Wu, L Wu, P Popov… - Cell, 2019 - cell.com
The cannabinoid receptor CB2 is predominately expressed in the immune system, and
selective modulation of CB2 without the psychoactivity of CB1 has therapeutic potential in …

Crystal structure of the human cannabinoid receptor CB1

T Hua, K Vemuri, M Pu, L Qu, GW Han, Y Wu, S Zhao… - Cell, 2016 - cell.com
Summary Cannabinoid receptor 1 (CB 1) is the principal target of Δ 9-tetrahydrocannabinol
(THC), a psychoactive chemical from Cannabis sativa with a wide range of therapeutic …

Structural basis of GABA reuptake inhibition

Z Motiwala, NG Aduri, H Shaye, GW Han, JH Lam… - Nature, 2022 - nature.com
Abstract γ-Aminobutyric acid (GABA) transporter 1 (GAT1) regulates neuronal excitation of
the central nervous system by clearing the synaptic cleft of the inhibitory neurotransmitter …

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

Y Kang, XE Zhou, X Gao, Y He, W Liu, A Ishchenko… - Nature, 2015 - nature.com
G-protein-coupled receptors (GPCRs) signal primarily through G proteins or arrestins.
Arrestin binding to GPCRs blocks G protein interaction and redirects signalling to numerous …

Cryo-EM structures of the TMEM16A calcium-activated chloride channel

S Dang, S Feng, J Tien, CJ Peters, D Bulkley… - Nature, 2017 - nature.com
Calcium-activated chloride channels (CaCCs) encoded by TMEM16A,, control neuronal
signalling, smooth muscle contraction, airway and exocrine gland secretion, and rhythmic …

A complex structure of arrestin-2 bound to a G protein-coupled receptor

W Yin, Z Li, M Jin, YL Yin, PW De Waal, K Pal, Y Yin… - Cell research, 2019 - nature.com
Arrestins comprise a family of signal regulators of G-protein-coupled receptors (GPCRs),
which include arrestins 1 to 4. While arrestins 1 and 4 are visual arrestins dedicated to …

The molecular mechanism of transport by the mitochondrial ADP/ATP carrier

JJ Ruprecht, MS King, T Zögg, AA Aleksandrova… - Cell, 2019 - cell.com
Mitochondrial ADP/ATP carriers transport ADP into the mitochondrial matrix for ATP
synthesis, and ATP out to fuel the cell, by cycling between cytoplasmic-open and matrix …

Anionic phospholipids control mechanisms of GPCR-G protein recognition

N Thakur, AP Ray, L Sharp, B Jin, A Duong… - Nature …, 2023 - nature.com
G protein-coupled receptors (GPCRs) are embedded in phospholipids that strongly
influence drug-stimulated signaling. Anionic lipids are particularly important for GPCR …