Modulators of microglial activation and polarization after intracerebral haemorrhage

X Lan, X Han, Q Li, QW Yang, J Wang - Nature Reviews Neurology, 2017 - nature.com
Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks
effective treatment. Microglia are among the first non-neuronal cells on the scene during the …

CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases

MS Subbarayan, A Joly-Amado, PC Bickford… - Pharmacology & …, 2022 - Elsevier
Neuroinflammation was initially thought of as a consequence of neurodegenerative disease
pathology, but more recently it is becoming clear that it plays a significant role in the …

The role of selected pro-inflammatory cytokines in pathogenesis of ischemic stroke

H Pawluk, A Woźniak, G Grześk… - … interventions in aging, 2020 - Taylor & Francis
Stroke is currently one of the most common causes of death and disability in the world, and
its pathophysiology is a complex process, involving the oxidative stress and inflammatory …

Microglial responses after ischemic stroke and intracerebral hemorrhage

RA Taylor, LH Sansing - Journal of Immunology Research, 2013 - Wiley Online Library
Stroke is a leading cause of death worldwide. Ischemic stroke is caused by blockage of
blood vessels in the brain leading to tissue death, while intracerebral hemorrhage (ICH) …

Pathophysiology and natural history of cervical spondylotic myelopathy

SK Karadimas, WM Erwin, CG Ely, JR Dettori… - Spine, 2013 - journals.lww.com
Study Design. This study is a combination of narrative and systematic review. Objective.
Clinicians who deal with cervical spondylotic myelopathy (CSM) should be up-to-date with …

The inflammatory response in stroke

Q Wang, XN Tang, MA Yenari - Journal of neuroimmunology, 2007 - Elsevier
Recent works in the area of stroke and brain ischemia has demonstrated the significance of
the inflammatory response accompanying necrotic brain injury. Acutely, this response …

Inflammatory responses in brain ischemia

M Kawabori, M A. Yenari - Current medicinal chemistry, 2015 - benthamdirect.com
Brain infarction causes tissue death by ischemia due to occlusion of the cerebral vessels
and recent work has shown that post stroke inflammation contributes significantly to the …

Neuron–glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage

GK Sheridan, KJ Murphy - Open biology, 2013 - royalsocietypublishing.org
An essential aspect of normal brain function is the bidirectional interaction and
communication between neurons and neighbouring glial cells. To this end, the brain has …

Microglia in the neurovascular unit: blood–brain barrier–microglia interactions after central nervous system disorders

H Thurgur, E Pinteaux - Neuroscience, 2019 - Elsevier
Over the past few decades, microglial cells have been regarded as the main executor of
inflammation after acute and chronic central nervous system (CNS) disorders, responding …

[HTML][HTML] Microglial activation in stroke: therapeutic targets

MA Yenari, TM Kauppinen, RA Swanson - Neurotherapeutics, 2010 - Elsevier
Microglial activation is an early response to brain ischemia and many other stressors.
Microglia continuously monitor and respond to changes in brain homeostasis and to specific …