Schizophrenia: a disorder of broken brain bioenergetics

ND Henkel, X Wu, SM O'Donovan, EA Devine… - Molecular …, 2022 - nature.com
A substantial and diverse body of literature suggests that the pathophysiology of
schizophrenia is related to deficits of bioenergetic function. While antipsychotics are an …

Inflammation and the two-hit hypothesis of schizophrenia

KA Feigenson, AW Kusnecov, SM Silverstein - … & Biobehavioral Reviews, 2014 - Elsevier
The high societal and individual cost of schizophrenia necessitates finding better, more
effective treatment, diagnosis, and prevention strategies. One of the obstacles in this …

The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice

P Zheng, B Zeng, M Liu, J Chen, J Pan, Y Han… - Science …, 2019 - science.org
Schizophrenia (SCZ) is a devastating mental disorder with poorly defined underlying
molecular mechanisms. The gut microbiome can modulate brain function and behaviors …

Blood-based biomarkers for Alzheimer's disease diagnosis and progression: an overview

A Varesi, A Carrara, VG Pires, V Floris, E Pierella… - Cells, 2022 - mdpi.com
Alzheimer's Disease (AD) is a progressive neurodegenerative disease characterized by
amyloid-β (Aβ) plaque deposition and neurofibrillary tangle accumulation in the brain …

[HTML][HTML] Metabolomics for the masses: The future of metabolomics in a personalized world

DK Trivedi, KA Hollywood, R Goodacre - New horizons in translational …, 2017 - Elsevier
Current clinical practices focus on a small number of biochemical directly related to the
pathophysiology with patients and thus only describe a very limited metabolome of a patient …

Integrative omics of schizophrenia: from genetic determinants to clinical classification and risk prediction

F Guan, T Ni, W Zhu, LK Williams, LB Cui, M Li… - Molecular …, 2022 - nature.com
Schizophrenia (SCZ) is a debilitating neuropsychiatric disorder with high heritability and
complex inheritance. In the past decade, successful identification of numerous susceptibility …

A systematic review of metabolite biomarkers of schizophrenia

J Davison, A O'Gorman, L Brennan, DR Cotter - Schizophrenia research, 2018 - Elsevier
Current diagnosis of schizophrenia relies exclusively on the potentially subjective
interpretation of clinical symptoms and social functioning as more objective biological …

Assessing the causal effects of human serum metabolites on 5 major psychiatric disorders

J Yang, B Yan, B Zhao, Y Fan, X He, L Yang… - Schizophrenia …, 2020 - academic.oup.com
Psychiatric disorders are the leading cause of disability worldwide while the pathogenesis
remains unclear. Genome-wide association studies (GWASs) have made great …

Identification and validation of urinary metabolite biomarkers for major depressive disorder

P Zheng, Y Wang, L Chen, D Yang, H Meng… - Molecular & Cellular …, 2013 - ASBMB
Major depressive disorder (MDD) is a widespread and debilitating mental disorder.
However, there are no biomarkers available to aid in the diagnosis of this disorder. In this …

Design of Multi‐Shelled Hollow Cr2O3 Spheres for Metabolic Fingerprinting

R Li, Y Zhou, C Liu, C Pei, W Shu… - Angewandte Chemie …, 2021 - Wiley Online Library
Schizophrenia (SZ) detection enables effective treatment to improve the clinical outcome,
but objective and reliable SZ diagnostics are still limited. An ideal diagnosis of SZ suited for …