Synaptopathies are a class of neurodevelopmental disorders caused by modification in
genes coding for synaptic proteins. These proteins oversee the process of …

The revolution in genetic technology has ushered in a new age for our understanding of the
underlying causes of neurodevelopmental, neuromuscular and neurodegenerative …

Ketamine produces rapid antidepressant action in patients with major depression or
treatment-resistant depression. Studies have identified brain-derived neurotrophic factor …

SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptor) complex,
composed of synaptobrevin, syntaxin, and SNAP25, forms the essential fusion machinery for …

Switches between global sleep and wakefulness states are believed to be dictated by top-
down influences arising from subcortical nuclei. Using forward genetics and in vivo …

Abstract Syntaxin 1B (STX1B) is a core component of the N-ethylmaleimide-sensitive factor
attachment protein receptor (SNARE) complex that is critical for the exocytosis of synaptic …

De novo heterozygous mutations in the STX1B gene, encoding syntaxin 1B, cause a
familial, fever‐associated epilepsy syndrome. Syntaxin 1B is an essential component of the …

Clinical and genetic features of five unrelated patients with de novo pathogenic variants in
the synaptic vesicle‐associated membrane protein 2 (VAMP2) reveal common features of …

Zebrafish is an emerging animal model for studying molecular mechanism underlying
neurodevelopmental disorder due to its advantage characters. miRNAs are small non …

Since the first report that Stxbp6, a brain-enriched protein, regulates the assembly of soluble
N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes, little has …