Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …

The AKT1, AKT2, and AKT3 kinases have emerged as critical mediators of signal
transduction pathways downstream of activated tyrosine kinases and phosphatidylinositol 3 …

CTLA-4 and PD-1 are receptors that negatively regulate T-cell activation. Ligation of both
CTLA-4 and PD-1 blocked CD3/CD28-mediated upregulation of glucose metabolism and …

Many functions of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) have
been defined, but relatively little is known about the biology of an alternative mTOR complex …

The serine/threonine protein kinase B (PKB, also known as Akt) constitutes an important
node in diverse signaling cascades downstream of growth factor receptor tyrosine kinases …

The activation of PI3K (phosphoinositide 3-kinase) family members is a universal event in
response to virtually all cytokines, growth factors and hormones. As a result of formation of …

Ceramide is generated in response to numerous stress-inducing stimuli and has been
implicated in the regulation of diverse cellular responses, including cell death …

Akt/PKB, a serine/threonine kinase member of the AGC family of proteins, is involved in the
regulation of a plethora of cellular processes triggered by a wide diversity of extracellular …

Akt/PKB is a key master regulator of a wide range of physiological functions including
metabolism, proliferation, survival, growth, angiogenesis and migration and invasion. The …

The phosphoinositide 3′ kinase signaling pathway is activated in response to a plethora of
growth factors and cytokines, and initiates a cascade of signaling events primarily via the …