Dynamic DNA assemblies in biomedical applications

Y Hu, Y Wang, J Yan, N Wen, H Xiong, S Cai… - Advanced …, 2020 - Wiley Online Library
Deoxyribonucleic acid (DNA) has been widely used to construct homogeneous structures
with increasing complexity for biological and biomedical applications due to their powerful …

Dynamic DNA nanostructures in biomedicine: Beauty, utility and limits

A Jahanban-Esfahlan, K Seidi, M Jaymand… - Journal of Controlled …, 2019 - Elsevier
DNA composite materials are at the forefront, especially for biomedical science, as they can
increase the efficacy and safety of current therapies and drug delivery systems. The …

DNA-walker-induced allosteric switch for tandem signal amplification with palladium nanoparticles/metal–organic framework tags in electrochemical biosensing

T Yan, L Zhu, H Ju, J Lei - Analytical chemistry, 2018 - ACS Publications
A DNA walker as a new molecular machine can walk on defined tracks to directly generate
signal indicators in biosensing and biomedical applications. In this work, a tandem signal …

Assembly of dynamic gated and cascaded transient DNAzyme networks

J Dong, Y Ouyang, J Wang, MP O'Hagan, I Willner - ACS nano, 2022 - ACS Publications
The dynamic transient formation and depletion of G-quadruplexes regulate gene replication
and transcription. This process was found to be related to various diseases such as cancer …

Label-free and sensitive electrochemical biosensor for amplification detection of target nucleic acids based on transduction hairpins and three-leg DNAzyme walkers

Y Xue, Y Wang, S Feng, M Yan, J Huang… - Analytical …, 2021 - ACS Publications
Nucleic acids are regarded as reliable biomarkers for the early diagnosis of various
diseases. By ingeniously combining a transduction hairpin (THP) with the toehold-mediated …

Regeneration of burnt bridges on a DNA catenane walker

J Valero, M Famulok - Angewandte Chemie International …, 2020 - Wiley Online Library
DNA walkers are molecular machines that can move with high precision onthe nanoscale
due to their structural and functional programmability. Despite recent advances in the field …

Molecular engineering of functional nucleic acid nanomaterials toward in vivo applications

JJ Zhang, T Lan, Y Lu - Advanced healthcare materials, 2019 - Wiley Online Library
Recent advances in nanotechnology and engineering have generated many nanomaterials
with unique physical and chemical properties. Over the past decade, numerous …

RNA-cleaving DNAzymes: Old catalysts with new tricks for intracellular and in vivo applications

JJ Zhang - Catalysts, 2018 - mdpi.com
DNAzymes are catalytically active DNA molecules that are normally isolated through in vitro
selection methods, among which RNA-cleaving DNAzymes that catalyze the cleavage of a …

Visible/near-infrared subdiffraction imaging reveals the stochastic nature of DNA walkers

J Pan, TG Cha, F Li, H Chen, NA Bragg, JH Choi - Science advances, 2017 - science.org
DNA walkers are designed with the structural specificity and functional diversity of
oligonucleotides to actively convert chemical energy into mechanical translocation …

Static DNA nanostructures for cancer theranostics: Recent progress in design and applications

R Jahanban-Esfahlan, K Seidi… - Nanotechnology …, 2019 - Taylor & Francis
Among the various nano/biomaterials used in cancer treatment, the beauty and benefits of
DNA nanocomposites are outstanding. The specificity and programmability of the base …