Regulation of proteolysis plays a critical role in a myriad of important cellular processes. The
key to better understanding the mechanisms that control this process is to identify the …

Enzymes generated by natural recruitment and protein engineering have greatly contribute
in various sets of applications. However, their insufficient stability is a bottleneck that limit the …

The I-TASSER server (http://zhanglab. ccmb. med. umich. edu/I-TASSER) is an online
resource for automated protein structure prediction and structure-based function annotation …

Four quantitative structure-activity relationships (QSAR) and quantitative structure-property
relationship (QSPR) data sets were selected from the literature and used to build regression …

Engineering proteins for thermostability is an exciting and challenging field since it is critical
for broadening the industrial use of recombinant proteins. Thermostability of proteins arises …

From a chemical point of view, enzymes are by far the most structurally complex and
functionally sophisticated molecules known. This is perhaps not surprising, once one …

Heliconius butterflies, a speciose genus of Müllerian mimics, represent a classic example of
an adaptive radiation that includes a range of derived dietary, life history, physiological and …

Elastic network models (ENMs) are entropic models that have demonstrated in many
previous studies their abilities to capture overall the important internal motions, with …

Determining the catalytic residues in an enzyme is critical to our understanding the
relationship between protein sequence, structure, function, and enhancing our ability to …

Protein evolvability includes two elements—robustness (or neutrality, mutations having no
effect) and innovability (mutations readily inducing new functions). How are these two …