Melatonin, an indoleamine hormone produced and secreted at night by pinealocytes and
extra-pineal cells, plays an important role in timing circadian rhythms (24-h internal clock) …

Despite considerable advances in the past few years, obesity and type 2 diabetes mellitus
(T2DM) remain two major challenges for public health systems globally. In the past 9 years …

Perivascular adipose tissue (PVAT) is an additional special type of adipose tissue
surrounding blood vessels. Under physiological conditions, PVAT plays a significant role in …

Metabolic syndrome (MetS) occurs in~ 30% of adults and is associated with increased risk of
cardiovascular disease and diabetes mellitus. MetS reflects the clustering of individual …

Background Oxidative stress, defined as an imbalance between pro-oxidants and
neutralizing antioxidants within the body, is a growing public health concern. Oxidative …

Obesity and periodontitis are both common health concerns that have given rise to
considerable economic and societal burden worldwide. There are established negative …

Diabetes mellitus (DM) and diabetes-related complications are amongst the leading causes
of mortality worldwide. The international diabetes federation (IDF) has estimated 592 million …

Background Obesity is a major public health problem whose prevalence has been rapidly
increasing in the United States (US), and globally. It is one of the leading causes of …

Exogenous melatonin is commonly used for sleep disorders in older adults, and its use is
increasing over time. It appears to have modest efficacy in treating insomnia and circadian …

Despite the evolving advances in clinical approaches to obesity and its inherent
comorbidities, the therapeutic challenge persists. Among several pharmacological tools …