Artificial biocatalytic linear cascades for preparation of organic molecules
JH Schrittwieser, S Velikogne, M Hall… - Chemical …, 2018 - ACS Publications
The review compiles artificial cascades involving enzymes with a focus on the last 10 years.
A cascade is defined as the combination of at least two reaction steps in a single reaction …
A cascade is defined as the combination of at least two reaction steps in a single reaction …
Applied biocatalysis beyond just buffers–from aqueous to unconventional media. Options and guidelines
MMCH van Schie, JD Spöring, M Bocola… - Green …, 2021 - pubs.rsc.org
In nature, enzymes conventionally operate under aqueous conditions. Because of this,
aqueous buffers are often the choice for reaction media when enzymes are applied in …
aqueous buffers are often the choice for reaction media when enzymes are applied in …
Metal-free photosensitized oxyimination of unactivated alkenes with bifunctional oxime carbonates
Abstract The 1, 2-aminoalcohol motif is one of the most prevalent structural components
found in high-value organic molecules, including pharmaceuticals and natural products …
found in high-value organic molecules, including pharmaceuticals and natural products …
Diastereodivergent Synthesis of β‐Amino Alcohols by Dual‐Metal‐Catalyzed Coupling of Alkoxyallenes with Aldimine Esters
M Zhu, Q Zhang, W Zi - Angewandte Chemie, 2021 - Wiley Online Library
Both syn‐and anti‐β‐amino alcohols are common structural motifs in natural products, drug
molecules, chiral ligands and catalysts. However, the currently available methods for …
molecules, chiral ligands and catalysts. However, the currently available methods for …
Building bridges: Biocatalytic C–C-bond formation toward multifunctional products
NG Schmidt, E Eger, W Kroutil - ACS catalysis, 2016 - ACS Publications
Carbon–carbon bond formation is the key reaction for organic synthesis to construct the
carbon framework of organic molecules. The review gives a selection of biocatalytic C–C …
carbon framework of organic molecules. The review gives a selection of biocatalytic C–C …
1, 2-Amino alcohols via Cr/photoredox dual-catalyzed addition of α-amino carbanion equivalents to carbonyls
JL Schwarz, R Kleinmans, TO Paulisch… - Journal of the American …, 2020 - ACS Publications
Herein, we report the synthesis of protected 1, 2-amino alcohols starting from carbonyl
compounds and α-silyl amines. The reaction is enabled by a Cr/photoredox dual catalytic …
compounds and α-silyl amines. The reaction is enabled by a Cr/photoredox dual catalytic …
Enzymatic and chemoenzymatic three‐step cascades for the synthesis of stereochemically complementary trisubstituted tetrahydroisoquinolines
V Erdmann, BR Lichman, J Zhao… - Angewandte Chemie …, 2017 - Wiley Online Library
Chemoenzymatic and enzymatic cascade reactions enable the synthesis of complex
stereocomplementary 1, 3, 4‐trisubstituted tetrahydroisoquinolines (THIQs) with three chiral …
stereocomplementary 1, 3, 4‐trisubstituted tetrahydroisoquinolines (THIQs) with three chiral …
Multistep mechanochemical synthesis of PZ-1190, a multitarget antipsychotic agent
V Canale, M Kamiński, W Trybała… - ACS Sustainable …, 2023 - ACS Publications
A solid-state approach was used to synthesize compound PZ-1190, a multitarget ligand for
serotonin and dopamine receptors with potential antipsychotic activity in rodents. Compared …
serotonin and dopamine receptors with potential antipsychotic activity in rodents. Compared …
[PDF][PDF] Is water the best solvent for biocatalysis
D Holtmann, F Hollmann - Mol. Catal, 2022 - pure.tudelft.nl
At first glance, the answer is quite obvious: water is the perfect solvent for biocatalytic
reactions. Life depends on water, living cells contain approx. 75% of water, most enzymes …
reactions. Life depends on water, living cells contain approx. 75% of water, most enzymes …
TBADT‐Mediated Photocatalytic Stereoselective Radical Alkylation of Chiral N‐Sulfinyl Imines: Towards Efficient Synthesis of Diverse Chiral Amines
M Leone, JP Milton, D Gryko, L Neuville… - … –A European Journal, 2024 - Wiley Online Library
Herein we describe a sustainable and efficient photocatalytic method for the stereoselective
radical alkylation of chiral sulfinyl imines. By employing readily available non …
radical alkylation of chiral sulfinyl imines. By employing readily available non …