the claim of consistent hemispheric specialisations across classes of chordates is
undermined by the absence of population-based directional asymmetry of paw/hand use in …

Nodal-related ligands of the transforming growth factor-beta (TGFβ) superfamily play central
roles in patterning the early embryo during the induction of mesoderm and endoderm and …

Cilia, as motile and sensory organelles, have been implicated in normal development, as
well as diseases including cystic kidney disease, hydrocephalus and situs inversus. In …

▪ Abstract TGFß signals belonging to the Nodal family set up the embryonic axes, induce
mesoderm and endoderm, pattern the nervous system, and determine left-right asymmetry in …

Genetic analyses in Drosophila have demonstrated that the multipass membrane protein
Smoothened (Smo) is essential for all Hedgehog signaling. We show that Smo acts epistatic …

The establishment of left-right asymmetry in mammals is a good example of how multiple
cell biological processes coordinate in the formation of a basic body plan. The leftward …

Forward-genetic analyses in Drosophila and Caenorhabditis elegans have given us
unprecedented insights into many developmental mechanisms. To study the formation of …

The generation of morphological, such as left–right, asymmetry during development is an
integral part of the establishment of a body plan. Until recently, the molecular basis of left …

The mammalian heart is crafted from a few progenitor cells that are subject to rapidly
changing sets of instructions from their environment and from within. These instructions …

The heart develops from two bilateral heart fields that are formed during early gastrulation. In
recent years, signaling pathways that specify cardiac mesoderm have been extensively …