Transporter-guided delivery of nanoparticles to improve drug permeation across cellular barriers and drug exposure to selective cell types

L Kou, YD Bhutia, Q Yao, Z He, J Sun… - Frontiers in …, 2018 - frontiersin.org
Targeted nano-drug delivery systems conjugated with specific ligands to target selective cell-
surface receptors or transporters could enhance the efficacy of drug delivery and therapy …

The role of albumin receptors in regulation of albumin homeostasis: Implications for drug delivery

M Bern, KMK Sand, J Nilsen, I Sandlie… - Journal of Controlled …, 2015 - Elsevier
Albumin is the most abundant protein in blood and acts as a molecular taxi for a plethora of
small insoluble substances such as nutrients, hormones, metals and toxins. In addition, it …

Vitamin B12 functionalized layer by layer calcium phosphate nanoparticles: A mucoadhesive and pH responsive carrier for improved oral delivery of insulin

A Verma, S Sharma, PK Gupta, A Singh, BV Teja… - Acta biomaterialia, 2016 - Elsevier
The present study investigates the potential of layer by layer coated calcium phosphate
nanoparticles–for oral delivery of insulin where Vitamin B12 grafted chitosan and sodium …

Nanoparticle delivery systems with cell-specific targeting for pulmonary diseases

Z Deng, GT Kalin, D Shi… - American journal of …, 2021 - atsjournals.org
Respiratory disorders are among the most important medical problems threatening human
life. The conventional therapeutics for respiratory disorders are hindered by insufficient drug …

PEGylated nanomedicines: recent progress and remaining concerns

D Vllasaliu, R Fowler, S Stolnik - Expert opinion on drug delivery, 2014 - Taylor & Francis
Introduction: Recent biopharma deals related to nanocarrier drug delivery technologies
highlight the emergence of nanomedicine. This is perhaps an expected culmination of many …

[HTML][HTML] Biotin receptor-mediated intracellular delivery of synthetic polypeptide-protein complexes

H Li, G Bruce, N Childerhouse, G Keegan… - Journal of Controlled …, 2023 - Elsevier
Pulmonary delivery offers a non-invasive route for the administration of biotherapeutics. In
this context, understanding and control of a transport into, and across cellular barriers is …

Oral drug delivery of nanomedicine

D Sahoo, R Bandaru, SK Samal, R Naik… - Theory and applications …, 2021 - Elsevier
Oral drug delivery is the most preferred administration route due to noninvasive, high patient
compliance, convenient to handle, and does not require any specific sterile conditions …

Recent advances in oral delivery of biologics: nanomedicine and physical modes of delivery

D Vllasaliu, M Thanou, S Stolnik… - Expert Opinion on Drug …, 2018 - Taylor & Francis
Introduction: Research into oral delivery of biologics has a long and rich history but has not
produced technologies used in the clinic. The area has evolved in terms of strategies to …

Formulation, characterization and in vitro anti-leishmanial evaluation of amphotericin B loaded solid lipid nanoparticles coated with vitamin B12-stearic acid conjugate

A Singh, G Yadagiri, S Parvez, OP Singh… - Materials Science and …, 2020 - Elsevier
Despite the advancement of new anti-leishmanials, amphotericin B (AmB) prevails as one of
the most potent agent in the treatment of visceral leishmaniasis (VL), a neglected tropical …

Transferrin functionization elevates transcytosis of nanogranules across epithelium by triggering polarity-associated transport flow and positive cellular feedback loop

D Yang, D Liu, H Deng, J Zhang, M Qin, L Yuan… - Acs Nano, 2019 - ACS Publications
Overcoming the epithelial barriers to enhance drug transport is a focused topic for
gastrointestinal, intratracheal, intranasal, vaginal, and intrauterine delivery. Nanomedicines …