3-3s represent a family of highly conserved 30 kDa acidic proteins. 14-3-3s recognize and
bind specific phospho-sequences on client partners and operate as molecular hubs to …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder,
characterized by prominent degeneration of dopaminergic neurons in the substantia nigra …

Leucine-rich repeat kinase 2 (LRRK2) is a kinase involved in different cellular functions,
including autophagy, endolysosomal pathways, and immune function. Mutations in LRRK2 …

Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain protein, and LRRK2 mutants
are recognized risk factors for Parkinson's disease (PD). Although the precise mechanisms …

14-3-3 proteins are a family of proteins expressed throughout the body and implicated in
many diseases, from cancer to neurodegenerative disorders. While these proteins do not …

Mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) gene are linked to autosomal
dominant Parkinson's disease (PD), and genetic variations at the LRRK2 locus are …

Mutations in LRRK2 cause familial Parkinson's disease and common variants increase
disease risk. LRRK2 kinase activity and cellular localization are tightly regulated by …

To explore how pathogenic mutations of the multidomain leucine-rich repeat kinase 2
(LRRK2) hijack its finely tuned activation process and drive Parkinson's disease (PD), we …

Proteins of the 14-3-3 family are well known modulators of the leucine-rich repeat kinase 2
(LRRK2) regulating kinase activity, cellular localization, and ubiquitylation. Although binding …

Our understanding of the mechanisms underlying Parkinson's disease, the once
archetypical nongenetic neurogenerative disorder, has dramatically increased with the …