The skeleton is an exquisitely sensitive and archetypal T3-target tissue that demonstrates
the critical role for thyroid hormones during development, linear growth, and adult bone …

Thyroid hormone action is predominantly mediated by thyroid hormone receptors (THRs),
which are encoded by the thyroid hormone receptor α (THRA) and thyroid hormone receptor …

Thyroid hormones (THs) play critical roles in the differentiation, growth, metabolism, and
physiological function of virtually all tissues. TH binds to receptors that are ligand …

BACKGROUND: Six known steps are required for the circulating thyroid hormone (TH) to
exert its action on target tissues. For three of these steps, human mutations and distinct …

Congenital hypothyroidism occurs in one of every three to four thousand newborns, owing to
complete or partial failure of thyroid gland development 1. Although thyroid hypoplasia has …

At least six major steps are required for secreted thyroid hormone (TH) to exert its action on
target tissues. Mutations interfering with three of these steps have been so far identified. The …

Objective: To determine the genetic and clinical features of resistance to thyroid hormone in
a study from a single institution. Design: Prospective, controlled study. Setting: National …

Resistance to thyroid hormone (RTH) is an inherited syndrome of reduced tissue
responsiveness to thyroid hormone. The first patient was reported by Refetoff, DeWind and …

The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) promotes
adipocyte differentiation, exerts atherogenic and anti-inflammatory effects in monocyte …

Steroid receptor co‐activator 1 (SRC‐1) is a transcription co‐factor that enhances the
hormone‐dependent action, mediated by the thyroid hormone (TH) receptor (TR) and other …