Metastasis is a dynamic succession of events involving the dissemination of tumour cells to
distant sites within the body, ultimately reducing the survival of patients with cancer. To …

Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Focal adhesion kinase (FAK) is a key regulator of growth factor receptor-and integrin-
mediated signals, governing fundamental processes in normal and cancer cells through its …

Blood and lymphatic vessels are lined by endothelial cells which constantly interact with
their luminal and abluminal extracellular environments. These interactions confer physical …

T cells engineered to express chimeric antigen receptors (CARs) can recognize and engage
with target cancer cells with redirected specificity for cancer immunotherapy. However, there …

Cells need to be anchored to extracellular matrix (ECM) to survive, yet the role of ECM in
guiding developmental processes, tissue homeostasis, and aging has long been …

Biological membranes are partitioned into functional zones termed membrane
microdomains, which contain specific lipids and proteins,–. The composition and …

Growth cones, found at the tip of axonal projections, are the sensory and motile organelles
of developing neurons that enable axon pathfinding and target recognition for precise wiring …

Genetic encoding of noncanonical amino acid (ncAA) for site-specific protein modification
has been widely applied for many biological and therapeutic applications. To efficiently …

Matrix mechanics controls cell fate by modulating the bonds between integrins and
extracellular matrix (ECM) proteins. However, it remains unclear how fibronectin (FN), type 1 …