SUMMARY A substantial amount of antisense transcription is a hallmark of gene expression
in eukaryotes. However, antisense transcription was first demonstrated in bacteria almost 50 …

The term 'transcriptional interference'(TI) is widely used but poorly defined in the literature.
There are a variety of methods by which one can interfere with the process or the product of …

Transcription rates are regulated by the interactions between RNA polymerase, sigma factor,
and promoter DNA sequences in bacteria. However, it remains unclear how non-canonical …

Dynamic regulation is a promising strategy for fine-tuning metabolic fluxes in microbial cell
factories. However, few of these synthetic regulatory systems have been developed for …

Computation underlies the organization of cells into higher-order structures, for example
during development or the spatial association of bacteria in a biofilm,,. Each cell performs a …

A molecular motor is made of either a single macromolecule or a macromolecular complex.
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …

The ability to determine full-length nucleotide composition of individual RNA molecules is
essential for understanding the architecture and function of a transcriptome. However …

RegulonDB is the internationally recognized reference database of Escherichia coli K-12
offering curated knowledge of the regulatory network and operon organization. It is currently …

Transcriptional interference is the in cis suppression of one transcriptional process by
another. Mathematical modeling shows that promoter occlusion by elongating RNA …

Synthetic genetic circuits offer the potential to wield computational control over biology, but
their complexity is limited by the accuracy of mathematical models. Here, we present …