Mechanisms and regulation of alternative pre-mRNA splicing

Y Lee, DC Rio - Annual review of biochemistry, 2015 - annualreviews.org
Precursor messenger RNA (pre-mRNA) splicing is a critical step in the posttranscriptional
regulation of gene expression, providing significant expansion of the functional proteome of …

Nascent RNA analyses: tracking transcription and its regulation

EM Wissink, A Vihervaara, ND Tippens… - Nature Reviews …, 2019 - nature.com
The programmes that direct an organism's development and maintenance are encoded in its
genome. Decoding of this information begins with regulated transcription of genomic DNA …

Exon-intron circular RNAs regulate transcription in the nucleus

Z Li, C Huang, C Bao, L Chen, M Lin, X Wang… - Nature structural & …, 2015 - nature.com
Noncoding RNAs (ncRNAs) have numerous roles in development and disease, and one of
the prominent roles is to regulate gene expression. A vast number of circular RNAs …

Coupling mRNA processing with transcription in time and space

DL Bentley - Nature Reviews Genetics, 2014 - nature.com
Maturation of mRNA precursors often occurs simultaneously with their synthesis by RNA
polymerase II (Pol II). The co-transcriptional nature of mRNA processing has permitted the …

Alternative splicing: a pivotal step between eukaryotic transcription and translation

AR Kornblihtt, IE Schor, M Alló, G Dujardin… - … reviews Molecular cell …, 2013 - nature.com
Alternative splicing was discovered simultaneously with splicing over three decades ago.
Since then, an enormous body of evidence has demonstrated the prevalence of alternative …

The roles of hnRNP A2/B1 in RNA biology and disease

Y Liu, SL Shi - Wiley Interdisciplinary Reviews: RNA, 2021 - Wiley Online Library
The RNA‐binding protein hnRNPA2/B1 is a member of the hnRNPs family and is widely
expressed in various tissues. hnRNPA2/B1 recognizes and binds specific RNA substrates …

Regulation of alternative splicing through coupling with transcription and chromatin structure

S Naftelberg, IE Schor, G Ast… - Annual review of …, 2015 - annualreviews.org
Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of
genetic information from DNA to proteins by expanding the coding capacity of genomes …

[HTML][HTML] SR proteins: binders, regulators, and connectors of RNA

S Jeong - Molecules and cells, 2017 - Elsevier
Serine and arginine-rich (SR) proteins are RNA-binding proteins (RBPs) known as
constitutive and alternative splicing regulators. As splicing is linked to transcriptional and …

[HTML][HTML] Epigenetics in alternative pre-mRNA splicing

RF Luco, M Allo, IE Schor, AR Kornblihtt, T Misteli - Cell, 2011 - cell.com
Alternative splicing plays critical roles in differentiation, development, and disease and is a
major source for protein diversity in higher eukaryotes. Analysis of alternative splicing …

Alternative splicing and protein diversity: plants versus animals

S Chaudhary, W Khokhar, I Jabre, ASN Reddy… - Frontiers in plant …, 2019 - frontiersin.org
Plants, unlike animals, exhibit a very high degree of plasticity in their growth and
development and employ diverse strategies to cope with the variations during diurnal cycles …