A bispecific T cell engager recruits both type 1 NKT and Vγ9Vδ2-T cells for the treatment of CD1d-expressing hematological malignancies
R Lameris, JM Ruben, V Iglesias-Guimarais… - Cell Reports …, 2023 - cell.com
Bispecific T cell engagers (bsTCEs) hold great promise for cancer treatment but face
challenges due to the induction of cytokine release syndrome (CRS), on-target off-tumor …
challenges due to the induction of cytokine release syndrome (CRS), on-target off-tumor …
Preclinical evaluation of invariant natural killer T cells modified with CD38 or BCMA chimeric antigen receptors for multiple myeloma
R Poels, E Drent, R Lameris, A Katsarou… - International journal of …, 2021 - mdpi.com
Due to the CD1d restricted recognition of altered glycolipids, Vα24-invariant natural killer T
(iNKT) cells are excellent tools for cancer immunotherapy with a significantly reduced risk for …
(iNKT) cells are excellent tools for cancer immunotherapy with a significantly reduced risk for …
A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response
Antibody-mediated modulation of major histocompatibility complex (MHC) molecules, or
MHC class I-like molecules, could constitute an effective immunotherapeutic approach. We …
MHC class I-like molecules, could constitute an effective immunotherapeutic approach. We …
Generation and characterization of CD1d‐specific single‐domain antibodies with distinct functional features
R Lameris, RCG de Bruin… - …, 2016 - Wiley Online Library
Ligation of the CD1d antigen‐presenting molecule by monoclonal antibodies (mAbs) can
trigger important biological functions. For therapeutic purposes camelid‐derived variable …
trigger important biological functions. For therapeutic purposes camelid‐derived variable …
Single domain antibodies targeting CD1d
JJ VAN DER VLIET, TD De Gruijl… - US Patent …, 2023 - Google Patents
C07K16/2809—Immunoglobulins [IGs], eg monoclonal or polyclonal antibodies against
material from animals or humans against receptors, cell surface antigens or cell surface …
material from animals or humans against receptors, cell surface antigens or cell surface …
In Vitro Detection of Cellular Adjuvant Properties of Human Invariant Natural Killer T Cells
R Zhang, S Kitayama, T Liu, N Ueda… - In Vitro Differentiation of …, 2019 - Springer
Invariant natural killer T (iNKT) cells are a subset of T lymphocytes that play a crucial role in
the tumor surveillance. The activation of iNKT cells by their specific ligand α …
the tumor surveillance. The activation of iNKT cells by their specific ligand α …
Single domain antibodies targeting CD1d
JJ VAN DER VLIET, TD De Gruijl… - US Patent …, 2019 - Google Patents
The invention relates to compounds, in particular polypeptides that specifically bind to the
non-classical MHC protein CD1d and modulate CD1d-mediated biological functions. The …
non-classical MHC protein CD1d and modulate CD1d-mediated biological functions. The …
Single domain antibodies targeting cd1d
JJ VAN DER VLIET, TD DE GRUIJL, HMW VERHEUL… - 2017 - Google Patents
VQFKFAKEUMHBLV-BYSUZVQFSA-N 1-O-(alpha-D-galactosyl)-N-
hexacosanoylphytosphingosine Chemical compound …
hexacosanoylphytosphingosine Chemical compound …