Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer

M Levin - Cell, 2021 - cell.com
How are individual cell behaviors coordinated toward invariant large-scale anatomical
outcomes in development and regeneration despite unpredictable perturbations …

Bioelectric signaling: role of bioelectricity in directional cell migration in wound healing

M Zhao, M Rolandi, RR Isseroff - Cold Spring Harbor …, 2022 - cshperspectives.cshlp.org
In wound healing, individual cells' behaviors coordinate movement toward the wound center
to restore small or large barrier defects. The migration of epithelial cells as a continuous …

Genetic and mechanical regulation of intestinal smooth muscle development

TR Huycke, BM Miller, HK Gill, NL Nerurkar, D Sprinzak… - Cell, 2019 - cell.com
The gastrointestinal tract is enveloped by concentric and orthogonally aligned layers of
smooth muscle; however, an understanding of the mechanisms by which these muscles …

Bioelectricity of non-excitable cells and multicellular pattern memories: Biophysical modeling

J Cervera, M Levin, S Mafe - Physics Reports, 2023 - Elsevier
Cells must coordinate their individual activities toward multicellular goals, which requires
efficient information processing mechanisms. Bioelectrical signals encode instructive rules …

Effects of electrical stimulation of the cell: wound healing, cell proliferation, apoptosis, and signal transduction

K Katoh - Medical Sciences, 2023 - mdpi.com
Electrical stimulation of the cell can have a number of different effects depending on the type
of cell being stimulated. In general, electrical stimulation can cause the cell to become more …

Calcium dynamics at the neural cell primary cilium regulate Hedgehog signaling–dependent neurogenesis in the embryonic neural tube

S Shim, R Goyal, AA Panoutsopoulos… - Proceedings of the …, 2023 - National Acad Sciences
The balance between neural stem cell proliferation and neuronal differentiation is
paramount for the appropriate development of the nervous system. Sonic hedgehog (Shh) is …

Molecular regulatory mechanisms in chicken feather follicle morphogenesis

G Ji, M Zhang, Y Tu, Y Liu, Y Shan, X Ju, J Zou, J Shu… - Genes, 2023 - mdpi.com
In China, the sale of freshly slaughtered chickens is becoming increasingly popular in
comparison with that of live chickens, and due to this emerging trend, the skin and feather …

Bioelectrical controls of morphogenesis: from ancient mechanisms of cell coordination to biomedical opportunities

JL Whited, M Levin - Current opinion in genetics & development, 2019 - Elsevier
Cell-to-cell communication is a cornerstone of multicellular existence. The ancient
mechanism of sharing information between cells using the conductance of ions across cell …

Mechanisms underlying influence of bioelectricity in development

LF George, EA Bates - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
To execute the intricate process of development, cells coordinate across tissues and organs
to determine where each cell divides and differentiates. This coordination requires complex …

L-type voltage-gated Ca2+ channel CaV1.2 regulates chondrogenesis during limb development

Y Atsuta, RR Tomizawa, M Levin… - Proceedings of the …, 2019 - National Acad Sciences
All cells, including nonexcitable cells, maintain a discrete transmembrane potential (V mem),
and have the capacity to modulate V mem and respond to their own and neighbors' changes …