The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-
phosphate (S1P), in yeast, plants and mammals have shown that it has important functions …

Lysophosphatidic acid (LPA) is one of the simplest glycerophospholipids with one fatty acid
chain and a phosphate group as a polar head. Although LPA had been viewed just as a …

Sphingosine 1-phosphate is formed in cells in response to diverse stimuli, including growth
factors, cytokines, G-protein-coupled receptor agonists, antigen, etc. Its production is …

We previously identified mutations in the Lpin1 gene, encoding lipin-1, as the underlying
cause of lipodystrophy in the fatty liver dystrophy (fld) mutant mouse. Lipin-1 is normally …

Eukaryotes are characterized by endomembranes that are connected by vesicular transport
along secretory and endocytic pathways. The compositional differences between the various …

Lysophosphatidic acid (LPA) is a bioactive phospholipid controlling numerous cellular
responses through the activation of specific G-protein coupled transmembrane receptors …

Lipid phosphates initiate key signaling cascades in cell activation. Lysophosphatidate (LPA)
and sphingosine 1‐phosphate (S1P) are produced by activated platelets. LPA is also formed …

The enzyme sphingosine kinase (SK) catalyzes the formation of sphingosine 1-phosphate
(S1P), a bioactive lipid that acts extracellularly on G protein-coupled receptors of the S1P …

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that acts either as an
intracellular messenger or as a ligand for its membrane receptors. S1P is a normal …

Lipid phosphate phosphatases (LPPs) regulate cell signaling by modifying the
concentrations of lipid phosphates versus their dephosphorylated products. The ecto-activity …