The actions of many drugs involve enzyme inhibition. This is exemplified by the inhibitors of
monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several …

Damage or loss of brain cells and impaired neurochemistry, neurogenesis, and synaptic and
nonsynaptic plasticity of the brain lead to dementia in neurodegenerative diseases, such as …

Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disorder.
Most existing treatments only provide symptomatic solutions. Here, we introduce currently …

Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …

Monoamine oxidases A and B (MAO A and B) are mammalian flavoenzymes bound to the
outer mitochondrial membrane. They were discovered almost a century ago and they have …

A series of hybrids of hydroxypyridinone and coumarin were rationally designed,
synthesized and biologically evaluated for their iron ion chelating and MAO-B inhibitory …

Abstract Mitochondrial calcium (Ca2+) dynamics play critical roles in regulating vital
physiological conditions in the brain. Importantly, Mitochondria‐associated endoplasmic …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading
cause of dementia worldwide. The limited pharmacological approaches based on …

Mitochondrial dysfunction is involved in the pathophysiology of psychiatric and
neurodegenerative disorders and can be used as a modulator and/or predictor of treatment …

Synapses are sites of high energy demand which are dependent on high levels of
mitochondrial derived adenosine triphosphate. Mitochondria within synaptic structures are …