Tumour-Associated Macrophages (TAMs) are one of the pivotal components of the tumour
microenvironment. Their roles in the cancer immunity are complicated, both pro-tumour and …

Abstract The SCUBE [Signal peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial
growth factor domain-containing protein] family consists of three proteins in vertebrates …

The infection of implants following orthopedic surgery is a “catastrophic” surgical
complication, particularly when biofilms form, protecting bacteria from antibiotics as well as …

Gastric cancer (GC) is difficult to characterize due to its heterogeneity, and the complicated
heterogeneity leads to the difficulty of precisely targeted therapy. The spatially …

Abstract Background Cancer‐associated fibroblasts (CAFs) are potential targets for cancer
therapy. Due to the heterogeneity of CAFs, the influence of CAF subpopulations on the …

Background Ovarian cancer (OC) is one of the most common malignancies in women. It has
a poor prognosis owing to its recurrence and metastasis. Unfortunately, reliable markers for …

Osteosarcoma is a common malignant bone tumour characterised by an aggressive
metastatic potential. The tumour microenvironment, particularly the M2‐polarised …

Introduction Gastric cancer (GC) is the fifth most common tumor, contributing to the third-
highest number of cancer-related deaths. Hypoxia is a major feature of the tumor …

TNF receptor superfamily member 11a (TNFRSF11a, RANK) and its ligand TNF superfamily
member 11 (TNFRSF11, RANKL) are overexpressed in many malignancies. However, the …

The journey of cancer development is a multifaceted and staged process. The array of
treatments available for cancer varies significantly, dictated by the disease's type and stage …