The building blocks and motifs of RNA architecture

NB Leontis, A Lescoute, E Westhof - Current opinion in structural biology, 2006 - Elsevier
RNA motifs can be defined broadly as recurrent structural elements containing multiple
intramolecular RNA–RNA interactions, as observed in atomic-resolution RNA structures …

Medicinal chemistry and bioinformatics-current trends in drugs discovery with networks topological indices

H Gonzalez-Diaz, S Vilar, L Santana… - Current topics in …, 2007 - ingentaconnect.com
The numerical encoding of chemical structure with Topological Indices (TIs) is currently
growing in importance in Medicinal Chemistry and Bioinformatics. This approach allows the …

Automated 3D structure composition for large RNAs

M Popenda, M Szachniuk, M Antczak… - Nucleic acids …, 2012 - academic.oup.com
Understanding the numerous functions that RNAs play in living cells depends critically on
knowledge of their three-dimensional structure. Due to the difficulties in experimentally …

Efficiently mining frequent trees in a forest

MJ Zaki - Proceedings of the eighth ACM SIGKDD international …, 2002 - dl.acm.org
Mining frequent trees is very useful in domains like bioinformatics, web mining, mining
semistructured data, and so on. We formulate the problem of mining (embedded) subtrees in …

Automated RNA 3D structure prediction with RNAComposer

M Biesiada, KJ Purzycka, M Szachniuk… - … : Methods and Protocols, 2016 - Springer
RNAs adopt specific structures to perform their activities and these are critical to virtually all
RNA-mediated processes. Because of difficulties in experimentally assessing structures of …

[HTML][HTML] Automated and fast building of three-dimensional RNA structures

Y Zhao, Y Huang, Z Gong, Y Wang, J Man, Y Xiao - Scientific reports, 2012 - nature.com
Building tertiary structures of non-coding RNA is required to understand their functions and
design new molecules. Current algorithms of RNA tertiary structure prediction give …

Proteomics, networks and connectivity indices

H González‐Díaz, Y González‐Díaz, L Santana… - …, 2008 - Wiley Online Library
Describing the connectivity of chemical and/or biological systems using networks is a
straight gate for the introduction of mathematical tools in proteomics. Networks, in some …

Computational approaches to RNA structure prediction, analysis, and design

C Laing, T Schlick - Current opinion in structural biology, 2011 - Elsevier
RNA molecules are important cellular components involved in many fundamental biological
processes. Understanding the mechanisms behind their functions requires RNA tertiary …

[HTML][HTML] Structure-altering mutations of the SARS-CoV-2 frameshifting RNA element

T Schlick, Q Zhu, S Jain, S Yan - Biophysical journal, 2021 - cell.com
With the rapid rate of COVID-19 infections and deaths, treatments and cures besides hand
washing, social distancing, masks, isolation, and quarantines are urgently needed. The …

Visualizing large RNA molecules in solution

A Gopal, ZH Zhou, CM Knobler, WM Gelbart - Biophysical Journal, 2012 - cell.com
Single-stranded (ss) RNAs longer than a few hundred nucleotides do not have a unique
structure in solution. Their equilibrium properties therefore reflect the average of an …