DNA methylation represents an annotation system for marking the genetic text, thus
providing instruction as to how and when to read the information and control transcription …

Despite constant research and public policy efforts, the obesity epidemic continues to be a
major public health threat, and new approaches are urgently needed. It has been shown that …

Human DNA-methylation data have been used to develop highly accurate biomarkers of
aging (" epigenetic clocks"). Recent studies demonstrate that similar epigenetic clocks for …

Cytosine DNA methylation is essential for mammalian development but understanding of its
spatiotemporal distribution in the developing embryo remains limited,. Here, as part of the …

Abstract Development in mammals is accompanied by specific de novo and demethylation
events that are thought to stabilize differentiated cell phenotypes. We demonstrate that a …

Upon activation by antigen, B cells form germinal centres where they clonally expand and
introduce affinity‐enhancing mutations into their B‐cell receptor genes. Somatic …

Abstract The type 2 deiodinase (D2) in the neonatal liver accelerates local thyroid hormone
triiodothyronine (T3) production and expression of T3-responsive genes. Here we show that …

Growth hormone-activated STAT5b is an essential regulator of sex-differential gene
expression in mouse liver; however, its impact on hepatic gene expression and epigenetic …

A basic question linked to differential patterns of gene expression is how cells reach different
fates despite using the same DNA template. Since 5-hydroxymethylcytosine (5hmC) …

Epigenetic regulation in the rumen, a unique ruminant organ, remains largely unexplored
compared with other tissues studied in model species. In this study, we perform an in-depth …