[HTML][HTML] Gene regulation by long non-coding RNAs and its biological functions
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
[HTML][HTML] Genome regulation by polycomb and trithorax: 70 years and counting
B Schuettengruber, HM Bourbon, L Di Croce, G Cavalli - Cell, 2017 - cell.com
Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …
modifying factors originally identified as part of an epigenetic cellular memory system that …
Unique features of long non-coding RNA biogenesis and function
Long non-coding RNAs (lncRNAs) are a diverse class of RNAs that engage in numerous
biological processes across every branch of life. Although initially discovered as mRNA-like …
biological processes across every branch of life. Although initially discovered as mRNA-like …
Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development
KM Anderson, DM Anderson, JR McAnally, JM Shelton… - Nature, 2016 - nature.com
HAND2 is an ancestral regulator of heart development and one of four transcription factors
that control the reprogramming of fibroblasts into cardiomyocytes,,,. Deletion of Hand2 in …
that control the reprogramming of fibroblasts into cardiomyocytes,,,. Deletion of Hand2 in …
Regulation of gene transcription by Polycomb proteins
S Aranda, G Mas, L Di Croce - Science advances, 2015 - science.org
The Polycomb group (PcG) of proteins defines a subset of factors that physically associate
and function to maintain the positional identity of cells from the embryo to adult stages. PcG …
and function to maintain the positional identity of cells from the embryo to adult stages. PcG …
Targeting Polycomb systems to regulate gene expression: modifications to a complex story
Polycomb group proteins are transcriptional repressors that are essential for normal gene
regulation during development. Recent studies suggest that Polycomb repressive …
regulation during development. Recent studies suggest that Polycomb repressive …
Polycomb and Trithorax Group Genes in Drosophila
JA Kassis, JA Kennison, JW Tamkun - Genetics, 2017 - academic.oup.com
Abstract Polycomb group (PcG) and Trithorax group (TrxG) genes encode important
regulators of development and differentiation in metazoans. These two groups of genes …
regulators of development and differentiation in metazoans. These two groups of genes …
The interaction of PRC2 with RNA or chromatin is mutually antagonistic
Polycomb repressive complex 2 (PRC2) modifies chromatin to maintain genes in a
repressed state during development. PRC2 is primarily associated with CpG islands at …
repressed state during development. PRC2 is primarily associated with CpG islands at …
Long noncoding RNA transcriptome of plants
J Liu, H Wang, NH Chua - Plant biotechnology journal, 2015 - Wiley Online Library
Since their discovery more than two decades ago, animal long noncoding RNA s (lnc RNA
s) have emerged as important regulators of many biological processes. Recently, a large …
s) have emerged as important regulators of many biological processes. Recently, a large …
Environmental perception and epigenetic memory: mechanistic insight through FLC
Chromatin plays a central role in orchestrating gene regulation at the transcriptional level.
However, our understanding of how chromatin states are altered in response to …
However, our understanding of how chromatin states are altered in response to …