Pax genes play key roles in the formation of tissues and organs during embryogenesis.
Pax3 and Pax7 mark myogenic progenitor cells and regulate their behavior and their entry …

Cranial placodes are specialized regions of the ectoderm, which give rise to various sensory
ganglia and contribute to the pituitary gland and sensory organs of the vertebrate head …

Populations of self-renewing cells that arise during normal embryonic development harbour
the potential for rapid proliferation, migration or transdifferentiation and, therefore, tumour …

Cranial placodes (which include the adenohypophyseal, olfactory, lens, otic, lateral line,
profundal/trigeminal, and epibranchial placodes) give rise to many sense organs and …

The peripheral nervous system responds to a wide variety of sensory stimuli, a process that
requires great neuronal diversity. These diverse neurons are closely associated with glial …

Specialized sensory organs in the vertebrate head originate from thickenings in the
embryonic ectoderm called cranial sensory placodes. These placodes, as well as the neural …

The mammalian cochlea is a remarkable sensory organ, capable of perceiving sound over a
range of 1012 in pressure, and discriminating both infrasonic and ultrasonic frequencies in …

Specification of Sox2+ proneurosensory progenitors within otic ectoderm is a prerequisite for
the production of sensory cells and neurons for hearing. However, the underlying molecular …

In the ENT region 50% of the malformations affect the ear. Malformations of the outer and
middle ear are predominantly unilateral (ca. 70-90%) and mostly involve the right ear. Inner …

Inner ear vestibular and spiral ganglion neurons (VGNs and SGNs) are known to play
pivotal roles in balance control and sound detection. However, the molecular mechanisms …