The liver is the only solid organ that uses regenerative mechanisms to ensure that the liver-
to-bodyweight ratio is always at 100% of what is required for body homeostasis. Other solid …

Acetaminophen (N-acetyl-para-aminophenol; APAP) overdose is the most common cause of
acute liver failure in the Western world, with limited treatment opportunities. For years …

Acetaminophen overdose is one of the leading causes of acute liver failure and liver
transplantation in the Western world. Magnesium is essential in several cellular processess …

Three-dimensional (3D) bioprinting is a promising technology to establish a 3D in vitro
hepatic model that holds great potential in toxicological evaluation. However, in current …

Acetaminophen (APAP)-induced injury is a common clinical phenomenon that not only
occurs in a dose-dependent manner but also occurs in some idiosyncratic individuals in a …

Acetaminophen (APAP) is an analgesic and antipyretic drug used worldwide, which is safe
at therapeutic doses. However, an overdose can induce liver injury and even liver failure …

Abstract In 2019 California's Office of Environmental Health Hazard Assessment (OEHHA)
initiated a review of the carcinogenic hazard potential of acetaminophen. In parallel with this …

One of the most used painkillers is acetaminophen (APAP), which is safe at the right dose.
However, several studies have described populations susceptible to APAP‐induced liver …

In high dosages, acetaminophen (APAP) can cause severe liver damage, but susceptibility
to liver failure varies across individuals and is influenced by factors such as health status …

Significance: During aging, excessive production of reactive species in the liver leads to
redox imbalance with consequent oxidative damage and impaired organ homeostasis …