Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …

Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a
global population of more than 35 million people living with HIV, there is intense interest in …

Despite scientific evidence originating from two patients published to date that
CCR5Δ32/Δ32 hematopoietic stem cell transplantation (HSCT) can cure human …

A cure for HIV-1 remains unattainable as only one case has been reported, a decade ago,.
The individual—who is known as the 'Berlin patient'—underwent two allogeneic …

Previously, two men were cured of HIV-1 through CCR5Δ32 homozygous (CCR5Δ32/Δ32)
allogeneic adult stem cell transplant. We report the first remission and possible HIV-1 cure in …

The latent viral reservoir is the critical barrier for the development of a cure for HIV-1
infection. Previous studies have shown direct antiviral activity of potent HIV-1 Env-specific …

Summary Background The London patient (participant 36 in the IciStem cohort) underwent
allogeneic stem-cell transplantation with cells that did not express CCR5 (CCR5Δ32/Δ32); …

HIV cure has been reported for five individuals who underwent allogeneic hematopoietic
stem cell transplantation (allo-HSCT) with cells from CCR5Δ32 homozygous donors. By …

The development of immunologic interventions that can target the viral reservoir in HIV-1-
infected individuals is a major goal of HIV-1 research,. However, little evidence exists that …

Objectives: Therapies to achieve sustained antiretroviral therapy-free HIV remission will
require validation in analytic treatment interruption (ATI) trials. Identifying biomarkers that …