Blood and lymphatic vessels pervade almost all body tissues and have numerous essential
roles in physiology and disease. The inner lining of these networks is formed by a single …

The mammalian circulatory system comprises both the cardiovascular system and the
lymphatic system. In contrast to the blood vascular circulation, the lymphatic system forms a …

Lymphedema affects up to 250 million people worldwide. The understanding of the
pathophysiology of the condition, however, is incomplete and a cure remains elusive. A …

The lymphatic system is fundamentally important to cardiovascular disease, infection and
immunity, cancer, and probably obesity—the four major challenges in healthcare in the 21st …

Generalized lymphatic dysplasia (GLD) is a rare form of primary lymphoedema
characterized by a uniform, widespread lymphoedema affecting all segments of the body …

Lymphatic anomalies include a variety of developmental and/or functional defects affecting
the lymphatic vessels: sporadic and familial forms of primary lymphedema, secondary …

Introduction Lymphedema is a chronic condition caused by the obstruction or impairment of
lymphatic fluid transport resulting in irreversible skin fibrosis. Besides conservative therapy …

Pathological lymphatic diseases mostly affect vessels in specific tissues, yet little is known
about organ-specific regulation of the lymphatic vasculature. Here, we show that the …

Gap junctions and hemichannels comprised of connexins impact many cellular processes.
Significant advances in our understanding of the functional role of these channels have …

Fluid shear forces have established roles in blood vascular development and function, but
whether such forces similarly influence the low-flow lymphatic system is unknown. It has …