Is curcumin bioavailability a problem in humans: Lessons from clinical trials

AB Kunnumakkara, C Harsha, K Banik… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Since ancient times, turmeric has been used in several folklore remedies
against various ailments. The principal component of turmeric is curcumin and its efficacy …

Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment

P Basnet, N Skalko-Basnet - Molecules, 2011 - mdpi.com
Oxidative damage and inflammation have been pointed out in preclinical studies as the root
cause of cancer and other chronic diseases such as diabetes, hypertension, Alzheimer's …

Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?

J Ravindran, S Prasad, BB Aggarwal - The AAPS journal, 2009 - Springer
Cancer is a hyperproliferative disorder that is usually treated by chemotherapeutic agents
that are toxic not only to tumor cells but also to normal cells, so these agents produce major …

Curcumin and cancer: an “old-age” disease with an “age-old” solution

P Anand, C Sundaram, S Jhurani, AB Kunnumakkara… - Cancer letters, 2008 - Elsevier
Cancer is primarily a disease of old age, and that life style plays a major role in the
development of most cancers is now well recognized. While plant-based formulations have …

New insights into therapeutic activity and anticancer properties of curcumin

AK Panda, D Chakraborty, I Sarkar… - Journal of experimental …, 2017 - Taylor & Francis
Natural compounds obtained from plants are capable of garnering considerable attention
from the scientific community, primarily due to their ability to check and prevent the onset …

Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials

AS Strimpakos, RA Sharma - Antioxidants & redox signaling, 2008 - liebertpub.com
Curcumin is a natural polyphenol used in ancient Asian medicine. Since the first article
referring to the use of curcumin to treat human disease was published in The Lancet in …

Mechanism of apoptosis induced by curcumin in colorectal cancer

NI Ismail, I Othman, F Abas, N H. Lajis… - International journal of …, 2019 - mdpi.com
Colorectal cancer (CRC) is among the top three cancer with higher incident and mortality
rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new …

Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects

M Purpura, RP Lowery, JM Wilson, H Mannan… - European journal of …, 2018 - Springer
Purpose The optimal health benefits of curcumin are limited by its low solubility in water and
corresponding poor intestinal absorption. Cyclodextrins (CD) can form inclusion complexes …

Curcumin and Apigenin–novel and promising therapeutics against chronic neuroinflammation in Alzheimer's disease

M Venigalla, E Gyengesi, G Münch - Neural regeneration …, 2015 - journals.lww.com
Alzheimer's disease is a progressive neurodegenerative disorder, characterized by
deposition of amyloid beta, neurofibrillary tangles, astrogliosis and microgliosis, leading to …

Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease

M Venigalla, S Sonego, E Gyengesi… - Neurochemistry …, 2016 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized by
deposition of amyloid plaques and neurofibrillary tangles, as well as microglial and …