Neural stem and progenitor cells have a central role in the development and evolution of the
mammalian neocortex. In this review, we first provide a set of criteria to classify the various …

Resolving lineage relationships between cells in an organism is a fundamental interest of
developmental biology. Furthermore, investigating lineage can drive understanding of …

Adeno-associated viruses (AAVs) are commonly used for in vivo gene transfer.
Nevertheless, AAVs that provide efficient transduction across specific organs or cell …

Cellular barcoding is a technique in which individual cells are labeled with unique nucleic
acid sequences, termed barcodes, so that they can be tracked through space and time …

Astrocytes play essential roles in the neural tissue where they form a continuous network,
while displaying important local heterogeneity. Here, we performed multiclonal lineage …

Photoreceptor degenerative diseases are a major cause of blindness for which cell
replacement is one of the most encouraging strategies. For stem cell-based therapy using …

One goal of systems neuroscience is a structure-function model of nervous system
organization that would allow mechanistic linking of mind, brain, and behavior. A necessary …

Communication, the effective delivery of information, is fundamental to life across all scales
and species. Nervous systems (by necessity) may be most specifically adapted among …

Multiphoton microscopy combined with genetically encoded fluorescent indicators is a
central tool in biology. Three-photon (3P) microscopy with excitation in the short-wavelength …

Tyrosine-type site-specific recombinases (T-SSRs) have opened new avenues for the
predictable modification of genomes as they enable precise genome editing in heterologous …