The remote but heart-encircling location of pericardial fluid confers this biofluid unique
properties. Once past the limitation of the invasive collection, for instance, on occasion of …

The pericardium is a double-layered fibro-serous sac that envelops the majority of the
surface of the heart as well as the great vessels. Pericardial fluid is also contained within the …

The clinical translation of regenerative therapy for the diseased heart, whether in the form of
cells, macromolecules or small molecules, is hampered by several factors: the poor retention …

Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Although
treatment options for AF exist, many patients cannot be maintained in normal sinus rhythm …

The pericardium, which surrounds the heart, provides a unique enclosed volume and a site
for the delivery of agents to the heart and coronary arteries. While strategies for targeting the …

Intrapericardial administration has been proposed as an alternative delivery route of
pharmacological agents via the bilaminar sac of pericardium surrounding the heart. To date …

Introduction: Local myocardial delivery (LMD) of therapeutic agents is a promising strategy
that aims to treat various myocardial pathologies. It is designed to deliver agents directly to …

The potential of the pericardial space as a therapeutic delivery tool for cardiac fibrosis and
heart failure (HF) treatment has yet to be elucidated. Recently, miRNAs and exosomes have …

Methods and Results: The effects of intrapericardial (IPC) administration of ranolazine (50-
mg bolus) on right atrial and right ventricular effective refractory periods (ERP), atrial …

Introduction: Intrapericardial (IPC) delivery of antiarrhythmic agents is an appealing idea to
increase the therapeutic width and reduce side effects of drugs, particularly in the thin atria …