Specificity, versatility, and control of TGF-β family signaling

R Derynck, EH Budi - Science signaling, 2019 - science.org
Encoded in mammalian cells by 33 genes, the transforming growth factor–β (TGF-β) family
of secreted, homodimeric and heterodimeric proteins controls the differentiation of most, if …

[HTML][HTML] Specification of BMP signaling

J Nickel, TD Mueller - Cells, 2019 - mdpi.com
Bone Morphogenetic Proteins (BMPs) together with the Growth and Differentiation Factors
(GDFs) form the largest subgroup of the Transforming Growth Factor (TGF) β family and …

Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β

Y Lan, D Zhang, C Xu, KW Hance, B Marelli… - Science translational …, 2018 - science.org
Antibodies targeting immune checkpoints are emerging as potent and viable cancer
therapies, but not all patients respond to these as single agents. Concurrently targeting …

Looking towards label-free biomolecular interaction analysis in a high-throughput format: a review of new surface plasmon resonance technologies

C Boozer, G Kim, S Cong, HW Guan… - Current opinion in …, 2006 - Elsevier
Surface plasmon resonance (SPR) biosensors have enabled a wide range of applications in
which researchers can monitor biomolecular interactions in real time. Owing to the fact that …

[HTML][HTML] Transforming growth factor-β family ligands can function as antagonists by competing for type II receptor binding

S Aykul, E Martinez-Hackert - Journal of Biological Chemistry, 2016 - ASBMB
Transforming growth factor-β (TGF-β) family ligands are pleiotropic cytokines. Their
physiological activities are not determined by a simple coupling of stimulus and response …

[HTML][HTML] Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer

M Shiroishi, K Kuroki, T Ose, L Rasubala… - Journal of Biological …, 2006 - ASBMB
HLA-G is a nonclassical major histocompatibility complex class I (MHCI) molecule, which is
expressed in trophoblasts and confers immunological tolerance in the maternal-fetal …

[HTML][HTML] The structural basis of TGF-β, bone morphogenetic protein, and activin ligand binding

SJ Lin, TF Lerch, RW Cook, TS Jardetzky… - …, 2006 - rep.bioscientifica.com
The transforming growth factor-β (TGF-β) superfamily is a large group of structurally related
growth factors that play prominent roles in a variety of cellular processes. The importance …

[HTML][HTML] TGF-β pathway in salivary gland fibrosis

X Zhang, JS Yun, D Han, JI Yook, HS Kim… - International journal of …, 2020 - mdpi.com
Fibrosis is presented in various physiologic and pathologic conditions of the salivary gland.
Transforming growth factor beta (TGF-β) pathway has a pivotal role in the pathogenesis of …

Advanced biosensors for nanomaterial-based detection of transforming growth factor alpha and beta, a class of major polypeptide regulators

S Gaba, U Jain - International Journal of Biological Macromolecules, 2023 - Elsevier
Transforming growth factors (TGFs) regulate several cellular processes including,
differentiation, growth, migration, extracellular matrix production, and apoptosis. TGF alpha …

Soluble endoglin, hypercholesterolemia and endothelial dysfunction

J Rathouska, K Jezkova, I Nemeckova, P Nachtigal - Atherosclerosis, 2015 - Elsevier
A soluble form of endoglin (sEng) is known to be an extracellular domain of the full-length
membrane endoglin, which is elevated during various pathological conditions related to …