β-Cell replacement by in situ reprogramming of non-β-cells is a promising diabetes therapy.
Following the observation that near-total β-cell ablation in adult mice triggers the …

There is a growing understanding that the early phases of type 1 diabetes (T1D) are
characterised by a deleterious dialogue between the pancreatic beta cells and the immune …

Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have
been generated, a consensus on pancreatic cell states in development, homeostasis and …

In commemoration of 100 years since the discovery of glucagon, we review current
knowledge about the human α cell. Alpha cells make up 30–40% of human islet endocrine …

Type 1 Diabetes (T1D) is a chronic autoimmune disease characterized by a gradual
destruction of insulin-producing β-cells in the endocrine pancreas due to innate and specific …

The pineal gland has evolved from a photoreceptive organ in fish to a neuroendocrine organ
in mammals. This study integrated multiple daytime single‐cell RNA‐seq datasets from the …

Aims/hypothesis Beta cells within the pancreatic islet represent a heterogenous population
wherein individual sub-groups of cells make distinct contributions to the overall control of …

Scrophularia ningpoensis Hemsl.(SN) is an herbal medicine used as a functional food in
China. SN has traditionally been used to treat diabetes mellitus (DM), but its mechanism of …

Diabetes cell replacement therapy has the potential to be transformed by human pluripotent
stem cell-derived β cells (SC-β cells). However, the precise identity of SC-β cells in …

The main hallmark in the development of both type 1 and type 2 diabetes is a decline in
functional β-cell mass. This decline is predominantly attributed to β-cell death, although …