The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

Maintenance of endothelial cell integrity is an important component of human health and
disease since the endothelium can perform various functions including regulation of …

Akt is a serine/threonine kinase and it participates in the key role of the PI3K signaling
pathway. The Akt can be activated by a wide range of growth signals and the biochemical …

Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

Major reactive oxygen species (ROS)–producing systems in vascular wall include NADPH
(reduced form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine oxidase …

The statins have been used for 30 years to prevent coronary artery disease and stroke. Their
primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic …

Carcinogenesis cannot be explained only by genetic alterations, but also involves
epigenetic processes. Modification of histones by acetylation plays a key role in epigenetic …

As the first discovered gaseous signaling molecule, nitric oxide (NO) affects a number of
cellular processes, including those involving vascular cells. This brief review summarizes …

NADPH oxidases (NOX) are enzyme complexes that have received much attention as key
molecules in the development of vascular dysfunction. NOX have the primary function of …