Epilepsy is a prevalent neurological disorder associated with significant morbidity and
mortality, but the only available drug therapies target its symptoms rather than the underlying …

The diversity of GABAA receptor (GABAAR) subunits and the numerous configurations
during subunit assembly give rise to a variety of receptors with different functional properties …

Key points A key mechanistic concept in epilepsy is the dentate gate hypothesis, which
argues that the dentate gyrus protects hippocampal circuits from overexcitation and that a …

Early life stress increases the risk for developing stress-related pathologies later in life.
Recent studies in rats suggest that mild early life stress, rather than being overall …

Rationale Neurosteroids are steroids synthesized within the brain with rapid effects on
neuronal excitability. Allopregnanolone, allotetrahydrodeoxycorticosterone, and …

The continuous incorporation of new neurons in the dentate gyrus of the adult hippocampus
raises exciting questions about memory and learning, and has inspired new computational …

Adult-born dentate granule neurons contribute to memory encoding functions of the dentate
gyrus (DG) such as pattern separation. However, local circuit-mechanisms by which adult …

Neurosteroids are key endogenous molecules in the brain that affect many neural functions.
We describe here recent advances in US National Institutes of Health (NIH)-sponsored and …

Robust incorporation of new principal cells into pre‐existing circuitry in the adult mammalian
brain is unique to the hippocampal dentate gyrus (DG). We asked if adult‐born granule cells …

The dentate gyrus has long been a focal point for studies on the molecular, cellular, and
network mechanisms responsible for epileptogenesis in temporal lobe epilepsy (TLE) …