PI3K/AKT/mTOR signaling in gastric cancer: Epigenetics and beyond

S Fattahi, F Amjadi-Moheb, R Tabaripour, GH Ashrafi… - Life Sciences, 2020 - Elsevier
Abstract PI3K/AKT/mTOR pathway is one of the most important signaling pathways involved
in normal cellular processes. Its aberrant activation modulates autophagy, epithelial …

Big roles for Fat cadherins

S Blair, H McNeill - Current opinion in cell biology, 2018 - Elsevier
To create an intricately patterned and reproducibly sized and shaped organ, many cellular
processes must be tightly regulated. Cell elongation, migration, metabolism, proliferation …

Only serum pepsinogen I and pepsinogen I/II ratio are specific and sensitive biomarkers for screening of gastric cancer

F Mansour-Ghanaei, F Joukar, M Baghaee… - Biomolecular …, 2019 - degruyter.com
Purpose We aimed to determine optimal cut-off points of plasma levels of ghrelin and serum
levels of pepsinogen I, II, and their ratio for screening of gastric cancer (GC). Methods Blood …

Epigenetic alterations of CYLD promoter modulate its expression in gastric adenocarcinoma: A footprint of infections

E Ghadami, N Nikbakhsh, S Fattahi… - Journal of cellular …, 2019 - Wiley Online Library
Gastric cancer (GC) is one of the most common causes of cancer‐related death in the world,
with multiple genetic and epigenetic alterations involved in disease development. CYLD …

FAT4 silencing promotes epithelial-to-mesenchymal transition and invasion via regulation of YAP and β-catenin activity in ovarian cancer

SH Malgundkar, I Burney, M Al Moundhri, M Al Kalbani… - BMC cancer, 2020 - Springer
Background The adhesion molecule, FAT4, has a tumor suppressor function with a critical
role in the epithelial-to-mesenchymal-transition (EMT) and anti-malignant growth in several …

Emerging mechanisms of growth and patterning regulation by dachsous and fat protocadherins

A Gridnev, JR Misra - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Dachsous (Ds) and Fat are evolutionarily conserved cell adhesion molecules that play a
critical role in development of multiple organ systems, where they coordinate tissue growth …

[HTML][HTML] Therapeutic approach of Cancer stem cells (CSCs) in gastric adenocarcinoma; DNA methyltransferases enzymes in cancer targeted therapy

SE Norollahi, F Mansour-Ghanaei, F Joukar… - Biomedicine & …, 2019 - Elsevier
Cancer stem cells (CSCs) show a remarkable sub class of cancer cells population which
have a potential to organize and regulate stemness properties which possess a main …

Genetic landscape and prognosis of conjunctival melanoma in Chinese patients

H Shi, H Tian, T Zhu, J Chen, S Jia, C Zong… - British Journal of …, 2024 - bjo.bmj.com
Aims Conjunctival melanoma (CoM) is a rare but highly lethal ocular melanoma and there is
limited understanding of its genetic background. To update the genetic landscape of CoM …

Identification of novel potential homologous repair deficiency-associated genes in pancreatic adenocarcinoma via WGCNA coexpression network analysis and …

C Liu, J Fang, W Kang, Y Yang, C Yu, H Chen… - Cell Cycle, 2023 - Taylor & Francis
Homologous repair deficiency (HRD) impedes double-strand break repair, which is a
common driver of carcinogenesis. Positive HRD status can be used as theranostic markers …

[HTML][HTML] Cancer signaling pathways with a therapeutic approach: An overview in epigenetic regulations of cancer stem cells

AA Samadani, SE Norollahi, A Rashidy-Pour… - Biomedicine & …, 2018 - Elsevier
One of the most important issues in cancer progression is caner stem cells (CSCs) which
have illustrated that the bulk tumors can arise from a special combination of cells …