This review provides an insight into mechanical properties that are critical to understanding
powder processing for tableting. Various parameters that reflect these basic fundamental …

Purpose To summarize the microstructure–property relationship of pharmaceutical tablets
and approaches to improve tablet properties through tablet microstructure engineering …

Great differences between published Heckel parameters, obtained from 'at pressure'data or
the 'in-die'method, are outlined. The general validity of the concept of yield pressures …

The quality of pharmaceutical products is essential to assure the maximum level of patient's
satisfaction. The most important criteria for quality of any drug in dosage form are its safety …

Processability of powders in high load compaction constitutes a challenge due to particle
rearrangement, compression and breakage occurring simultaneously. Although tableting is …

Polymorphs enable us to gain molecular insights into the compaction behavior of
pharmaceutical powders. Two polymorphs (α and γ) of indomethacin (IMC) were …

In-die compression analysis is an effective method for the characterization of powder
compressibility. However, physically unreasonable apparent solid fractions above one or …

Numerous studies elucidated material behavior based on compression analyses. Especially
compressibility, compactibility and tabletability were in the focus of these investigations. In …

The background, theoretical and experimental requirements of powder compaction
equations have been briefly reviewed in this paper. There have been many equations …

Compressibility properties of pharmaceutical materials are widely characterized by
measuring the volume reduction of a powder column under pressure. Experimental data are …