[HTML][HTML] Preparing for the next viral threat with broad-spectrum antivirals
There is a large global unmet need for the development of countermeasures to combat
hundreds of viruses known to cause human disease and for the establishment of a …
hundreds of viruses known to cause human disease and for the establishment of a …
[HTML][HTML] Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals
J Kottur, KM White, ML Rodriguez, O Rechkoblit… - PLoS …, 2023 - journals.plos.org
The RNA N7-methyltransferase (MTase) activity of SARS-CoV-2's nsp14 protein is essential
for viral replication and is a target for the development of new antivirals. Nsp14 uses S …
for viral replication and is a target for the development of new antivirals. Nsp14 uses S …
[HTML][HTML] Structural basis for RNA-cap recognition and methylation by the mpox methyltransferase VP39
P Skvara, D Chalupska, M Klima, J Kozic, J Silhan… - Antiviral Research, 2023 - Elsevier
Mpox is a zoonotic disease caused by the mpox virus (MPXV), which has gained attention
due to its rapid and widespread transmission, with reports from more than 100 countries …
due to its rapid and widespread transmission, with reports from more than 100 countries …
Nsp14 of SARS-CoV-2 inhibits mRNA processing and nuclear export by targeting the nuclear cap-binding complex
J Katahira, T Ohmae, M Yasugi, R Sasaki… - Nucleic Acids …, 2023 - academic.oup.com
To facilitate selfish replication, viruses halt host gene expression in various ways. The
nuclear export of mRNA is one such process targeted by many viruses. SARS-CoV-2, the …
nuclear export of mRNA is one such process targeted by many viruses. SARS-CoV-2, the …
Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases
M Hausdorff, A Delpal, S Barelier, L Nicollet… - European Journal of …, 2023 - Elsevier
The COVID-19 pandemic reveals the urgent need to develop new therapeutics targeting the
SARS-CoV-2 replication machinery. The first antiviral drugs were nucleoside analogues …
SARS-CoV-2 replication machinery. The first antiviral drugs were nucleoside analogues …
5′-cap RNA/SAM mimetic conjugates as bisubstrate inhibitors of viral RNA cap 2′-O-methyltransferases
R Ahmed-Belkacem, P Sutto-Ortiz, A Delpal… - Bioorganic …, 2024 - Elsevier
Abstract Viral RNA cap 2′-O-methyltransferases are considered promising therapeutic
targets for antiviral treatments, as they play a key role in the formation of viral RNA cap-1 …
targets for antiviral treatments, as they play a key role in the formation of viral RNA cap-1 …
[HTML][HTML] Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical …
H Chen, S Lin, F Yang, Z Chen, L Guo, J Yang… - PLoS …, 2023 - journals.plos.org
Alongshan virus (ALSV), a newly discovered member of unclassified Flaviviridae family, is
able to infect humans. ALSV has a multi-segmented genome organization and is …
able to infect humans. ALSV has a multi-segmented genome organization and is …
[HTML][HTML] Application of established computational techniques to identify potential SARS-CoV-2 Nsp14-MTase inhibitors in low data regimes
AK Nigam, MFD Hurley, F Li, E Konkoľová, M Klíma… - Digital …, 2024 - pubs.rsc.org
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to significant global
morbidity and mortality. A crucial viral protein, the non-structural protein 14 (nsp14) …
morbidity and mortality. A crucial viral protein, the non-structural protein 14 (nsp14) …
[HTML][HTML] Structure-Based Virtual Screening for Methyltransferase Inhibitors of SARS-CoV-2 nsp14 and nsp16
K Wu, Y Guo, T Xu, W Huang, D Guo, L Cao, J Lei - Molecules, 2024 - mdpi.com
The ongoing COVID-19 pandemic still threatens human health around the world. The
methyltransferases (MTases) of SARS-CoV-2, specifically nsp14 and nsp16, play crucial …
methyltransferases (MTases) of SARS-CoV-2, specifically nsp14 and nsp16, play crucial …
Structural biology of SARS-CoV-2 exoribonuclease/N7–methyltransferase (nsp14), 2′–O–methyltransferase (nsp16) and their enhancing protein (nsp10)
Coronaviruses have a very large genome of up to 32 kb in length, almost two thirds of which
encode for proteins involved in the production of the virus's own RNA. Due to the inherent …
encode for proteins involved in the production of the virus's own RNA. Due to the inherent …