Neurofluids is a term introduced to define all fluids in the brain and spine such as blood,
cerebrospinal fluid, and interstitial fluid. Neuroscientists in the past millennium have steadily …

The central nervous system (CNS) was previously thought to be the only organ system
lacking lymphatic vessels to remove waste products from the interstitial space. Recently …

Purpose The diffusion tensor image analysis along the perivascular space (DTI-ALPS)
method was developed to evaluate the brain's glymphatic function or interstitial fluid …

Clearance of neurotoxic brain proteins via cerebrospinal fluid (CSF) to blood has recently
emerged to be crucial, and plasma biomarkers of neurodegeneration were newly introduced …

Purpose The purpose of this study was to evaluate the interstitial fluid status in a wide range
of age groups using diffusion-weighted image analysis along the perivascular space (DWI …

The concept of the glymphatic system was proposed more than a decade ago as a
mechanism for interstitial fluid flow and waste removal in the central nervous system. The …

After the introduction of the glymphatic system hypothesis, an increasing number of studies
on cerebrospinal fluid and interstitial fluid dynamics within the brain have been investigated …

Brain fluid dynamics remains poorly understood with central issues unresolved. In this study,
we first review the literature regarding points of controversy, then pilot study if conventional …

Idiopathic normal pressure hydrocephalus (iNPH) is a neurodegenerative disease,
characterized by cerebrospinal fluid (CSF) flow disturbance. Today, the only available …

BACKGROUND AND PURPOSE: In our clinical practice, we increasingly use intrathecal
contrast-enhanced glymphatic MR imaging to assess CSF disturbances. However, because …