Half a century of amyloids: past, present and future
Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …
implications and yet remain without a cure. This dire situation calls for research into the …
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies
Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of
late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk …
late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk …
Emerging near infrared fluorophore: Dicyanoisophorone-based small-molecule fluorescent probes with large stokes shifts for bioimaging
L Dai, Q Zhang, Q Ma, W Lin - Coordination Chemistry Reviews, 2023 - Elsevier
Dicyanoisophorone (DCI) has been used extensively as a quality acceptor for designing
chemical sensors targeting different analytes, and developing a series of well-established …
chemical sensors targeting different analytes, and developing a series of well-established …
α-synuclein in the pathophysiology of Alzheimer's disease
D Twohig, HM Nielsen - Molecular neurodegeneration, 2019 - Springer
The Alzheimer's disease (AD) afflicted brain is neuropathologically defined by extracellular
amyloid-β (Aβ) plaques and intraneuronal neurofibrillary tangles composed of …
amyloid-β (Aβ) plaques and intraneuronal neurofibrillary tangles composed of …
Apolipoprotein E, receptors, and modulation of Alzheimer's disease
Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous
systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to …
systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to …
[PDF][PDF] Apolipoprotein E4 impairs neuronal insulin signaling by trapping insulin receptor in the endosomes
Diabetes and impaired brain insulin signaling are linked to the pathogenesis of Alzheimer's
disease (AD). The association between diabetes and AD-associated amyloid pathology is …
disease (AD). The association between diabetes and AD-associated amyloid pathology is …
[HTML][HTML] Dysregulation of ubiquitin-proteasome system in neurodegenerative diseases
The ubiquitin-proteasome system (UPS) is one of the major protein degradation pathways,
where abnormal UPS function has been observed in cancer and neurological diseases …
where abnormal UPS function has been observed in cancer and neurological diseases …
ApoE lipidation as a therapeutic target in Alzheimer's disease
MF Lanfranco, CA Ng, GW Rebeck - International journal of molecular …, 2020 - mdpi.com
Apolipoprotein E (APOE) is the major cholesterol carrier in the brain, affecting various
normal cellular processes including neuronal growth, repair and remodeling of membranes …
normal cellular processes including neuronal growth, repair and remodeling of membranes …
Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies: Thematic Review Series: ApoE and Lipid Homeostasis in …
M Shinohara, M Tachibana, T Kanekiyo, G Bu - Journal of lipid research, 2017 - ASBMB
Among the LDL receptor (LDLR) family members, the roles of LDLR-related protein (LRP) 1
in the pathogenesis of Alzheimer's disease (AD), especially late-onset AD, have been the …
in the pathogenesis of Alzheimer's disease (AD), especially late-onset AD, have been the …
Astrocytic LRP1 mediates brain Aβ clearance and impacts amyloid deposition
Accumulation and deposition of amyloid-β (Aβ) in the brain represent an early and perhaps
necessary step in the pathogenesis of Alzheimer's disease (AD). Aβ accumulation leads to …
necessary step in the pathogenesis of Alzheimer's disease (AD). Aβ accumulation leads to …