Antimicrobial resistance (AMR) is a high priority across countries as it increases morbidity,
mortality and costs. Concerns with AMR have resulted in multiple initiatives internationally …

Preventing human-to-mosquito transmission of malaria parasites provides possible
solutions to interrupt the malaria parasite life cycle for malaria elimination. The development …

Fungal infections cause more than 1.5 million deaths a year. Due to emerging antifungal
drug resistance, novel strategies are urgently needed to combat life-threatening fungal …

Compounds acting on multiple targets are critical to combating antimalarial drug resistance.
Here, we report that the human “mammalian target of rapamycin”(mTOR) inhibitor …

To ensure their survival in the human bloodstream, malaria parasites degrade up to 80% of
the host erythrocyte hemoglobin in an acidified digestive vacuole. Here, we combine …

Structure–activity relationship studies of 2, 8-disubstituted-1, 5-naphthyridines, previously
reported as potent inhibitors of Plasmodium falciparum (Pf) phosphatidylinositol-4-kinase β …

The current Covid-19 pandemic has underlined the need for a more coordinated and
forward-looking investment in the search for new medicines targeting emerging health care …

Antimalarial drug discovery has until recently been driven by high‐throughput phenotypic
cellular screening, allowing millions of compounds to be assayed and delivering clinical …

Artemisinin-based combination therapies have been crucial in driving down the global
burden of malaria, the world's largest parasitic killer. However, their efficacy is now …

Microsporidia are fungal obligate intracellular pathogens, which infect most animals and
cause microsporidiosis. Despite the serious threat that microsporidia pose to humans and …