The NLR gene family: from discovery to present day
The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …
genes that were later grouped into the family were already known at that time. Although it is …
DNA sensing by the cGAS–STING pathway in health and disease
The detection of pathogens through nucleic acid sensors is a defining principle of innate
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …
Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy
Z Zhang, H Zhou, X Ouyang, Y Dong… - Signal transduction and …, 2022 - nature.com
Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …
Fiery cell death: pyroptosis in the central nervous system
Pyroptosis ('fiery death') is an inflammatory type of regulated cell death (RCD), which occurs
downstream of inflammasome activation. Pyroptosis is mediated directly by the recently …
downstream of inflammasome activation. Pyroptosis is mediated directly by the recently …
Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets
V Kumar - International immunopharmacology, 2020 - Elsevier
Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …
Mitochondria in innate immune signaling
B Banoth, SL Cassel - Translational Research, 2018 - Elsevier
Mitochondria are functionally versatile organelles. In addition to their conventional role of
meeting the cell's energy requirements, mitochondria also actively regulate innate immune …
meeting the cell's energy requirements, mitochondria also actively regulate innate immune …
The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum
Stimulator of interferon genes (STING) is an endoplasmic reticulum (ER) signaling adaptor
that is essential for the type I interferon response to DNA pathogens. Aberrant activation of …
that is essential for the type I interferon response to DNA pathogens. Aberrant activation of …
Research advances in how the cGAS-STING pathway controls the cellular inflammatory response
D Wan, W Jiang, J Hao - Frontiers in immunology, 2020 - frontiersin.org
Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …
STING signaling and host defense against microbial infection
J Ahn, GN Barber - Experimental & molecular medicine, 2019 - nature.com
The first line of host defense against infectious agents involves activation of innate immune
signaling pathways that recognize specific pathogen-associated molecular patterns …
signaling pathways that recognize specific pathogen-associated molecular patterns …
Dendritic cell subsets
Dendritic cells (DC) are professional antigen presenting cells comprising a variety of
subsets, as either resident or migrating cells, in lymphoid and non-lymphoid organs. In the …
subsets, as either resident or migrating cells, in lymphoid and non-lymphoid organs. In the …